ID   MUTL_CLOAB              Reviewed;         622 AA.
AC   Q97I20;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CA_C1836;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE001437; AAK79800.1; -; Genomic_DNA.
DR   PIR; E97126; E97126.
DR   RefSeq; NP_348460.1; NC_003030.1.
DR   RefSeq; WP_010965141.1; NC_003030.1.
DR   AlphaFoldDB; Q97I20; -.
DR   SMR; Q97I20; -.
DR   STRING; 272562.CA_C1836; -.
DR   EnsemblBacteria; AAK79800; AAK79800; CA_C1836.
DR   GeneID; 44998329; -.
DR   KEGG; cac:CA_C1836; -.
DR   PATRIC; fig|272562.8.peg.2041; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..622
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177940"
SQ   SEQUENCE   622 AA;  71065 MW;  D372ED449865011A CRC64;
     MRINILSEDT SNKIAAGEVV ERPFSVVKEL VENSIDAGAK TINIEIENGG RTLIKVLDDG
     YGIDKDDIEK AFMPHATSKI SKLQDIYSIN TLGFRGEALP SIASVSKTTL KSRTKENEFG
     REISISGGSV DYIKDCGTNI GTHIEVRDLF YNVPAREKFL KSTAKEASSI SDIVNRLALA
     HSEISFRLIN NGKRVITTYA TDNLIDTIRA IYGKKICDNV ISFERHTDLV SVHGYVGNAE
     ISRGSRNNQS IFINKRYIKN KLITAAVENA VKSFMMINKF PFFIIFLDIF PEFVDVNVHP
     TKSEVKFQNE RDIFKIIFDT VHEGIRNSLK ESFKVEALKE EEDKLFDIKE DVITKNEIKH
     DDKIDGYIKK DSFPVPVQIP IDLKRPIENY DNSTKENKDR SFDDFREKDI IKETSQEKET
     YDIITNKKAK FPELRVIGQF NNTYILAESF EELYIIDQHA AHEKILFEKY REDIKNKGVS
     SQILITPSVV ELLPEDFIYY DENKEVFKNA GFVIEYFGDN TVAIKEVPLF LGKPLVKDLF
     LEIIDNLKNM GSGETSEVKY RSIATAACKS AVKAYHELTH DEMKTLIQDL RFAEDPFNCP
     HGRPTIVRLT VTDFEKKFKR IQ