ID   MUTL_CLOB6              Reviewed;         666 AA.
AC   C3KX34;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CLJ_B1977;
OS   Clostridium botulinum (strain 657 / Type Ba4).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=515621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=657 / Type Ba4;
RA   Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.S.;
RT   "Genome sequence of Clostridium botulinum Ba4 strain 657.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001083; ACQ55138.1; -; Genomic_DNA.
DR   RefSeq; WP_012721416.1; NC_012658.1.
DR   AlphaFoldDB; C3KX34; -.
DR   SMR; C3KX34; -.
DR   EnsemblBacteria; ACQ55138; ACQ55138; CLJ_B1977.
DR   KEGG; cbi:CLJ_B1977; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002333; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..666
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203383"
SQ   SEQUENCE   666 AA;  76144 MW;  0BB523106A70C37A CRC64;
     MRKINLLDLE TTNKIAAGEV IERPFSVVKE LVENSIDAGA KNITIEIEDG GQKLIKIIDD
     GEGIYPIDIK NAFLPHATSK INSIEDIYKI STMGFRGEAL ASISSVSKTK LKSRVDSYNF
     GKEIYIEGGK IEYLKDTGCN VGTTIEVSDL FYNVPARLKF LKSARSDSSA ISDIVNRFIL
     AHPDISFNLI NKGKQSIKSY GTGNLKDSIR CVYNKTISEN LINFENHKDI ISVYGFIGKP
     EISRKSRTNQ SIFVNKRYVK SKFITAAVEN AFKSFLTVNS YPFFVIFIDI FPEYIDVNVH
     PTKSEVKFKD ERAMFKTIFD AVHEAIKGEL KESFTNFFNK EDINIYDSEK SIAETIKPGK
     EEVQIPIDLN SNNKIDIFGN NINKLPNNTE LLKNIDIKEK NILENNDNFY TSNQNEIYYT
     NKNDKCLNSC NKDDYSKIEK PLQKDNKNLD NLYLNEHNTN SSSINIKENK PNNFYVDMKI
     IGQFNNTYIL IEKDKELYII DQHAAHEKVL FEKFKSEIEK GYVVSQILLS PVVIELSEDE
     FNIYEENKDI FKNSGFSVEA FGECTINIKE VPLILGKPNV ENLFMDILYN LKNMKSKETS
     TIKYNAIATL ACKSAVKAND NLKEEEIKKL IEDMLILNNP YTCPHGRPTM IKFTLKDLEK
     KFKRIQ