ID   MUTL_CLOB8              Reviewed;         664 AA.
AC   A6LWJ1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Cbei_2565;
OS   Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS   acetobutylicum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=290402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51743 / NCIMB 8052;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G.,
RA   Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W.,
RA   Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B.,
RA   Blaschek H., Richardson P.;
RT   "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000721; ABR34721.1; -; Genomic_DNA.
DR   RefSeq; WP_012058776.1; NC_009617.1.
DR   AlphaFoldDB; A6LWJ1; -.
DR   SMR; A6LWJ1; -.
DR   STRING; 290402.Cbei_2565; -.
DR   EnsemblBacteria; ABR34721; ABR34721; Cbei_2565.
DR   KEGG; cbe:Cbei_2565; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000565; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..664
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076693"
SQ   SEQUENCE   664 AA;  75210 MW;  A45729D3FCC9EB5A CRC64;
     MKRINILNED TANKIAAGEV VERPASVVKE LIENSIDANA KNIIIEIEEG GISLIRIIDD
     GDGIYKDDIA KAFLPHATSK IQESEDIYNI HTLGFRGEAL PSIASVGKVN LKSKQDEEAF
     GYEISIEGGK ASEVTECGIN KGTILEVQDL FFNVPARKKF LKSVSKESSL INDIVTRLSL
     ANPKISFKLY NNHKKVLHTF GNGDLKDVIR TIYGKSITDN ILYFSDSSDL ITVYGYVGTE
     EIARGSRNNQ SIFVNRRYIK NRALAIAVEQ AFKSFSTVNK FPFFILFIEV YPEYVDVNIH
     PTKAEIKFND ERMIFKKIFG AVHTALKNEV FETFAIKEEE NTKKEPLPTF EEITFKIKEE
     EEKVKFASSA AKTLISQGKD LKANNESSFK SVYDPSLNNI NKTIVEESTD YNKENEEPIS
     IPVDLKPNSY IENLVDDYSD NAEDEIKSNS EPIENVITEN KYENIKPNPI AKFPPITIIG
     QYNKTYILGE YDGTLYMIDQ HAAHEKILFE KYLKEIEEGT IIIQPLIVPS IIDLSIDDYS
     YFEENKDIFR EAGFLLEEFG GSSLSLKEVP YFLGRLNPKN LFLDILDNLK NLGNGKTSEV
     KHNAIATKAC KAAIKGNDKL EMNEMIKLIE DLRYIDDPFH CPHGRPVIIK FTSIDIDKKF
     KRII