ID   MUTL_CLOBB              Reviewed;         672 AA.
AC   B2TIB8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CLL_A1818;
OS   Clostridium botulinum (strain Eklund 17B / Type B).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=935198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Eklund 17B / Type B;
RA   Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.S.;
RT   "Complete sequence of Clostridium botulinum strain Eklund.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001056; ACD22307.1; -; Genomic_DNA.
DR   RefSeq; WP_012423173.1; NC_018648.1.
DR   AlphaFoldDB; B2TIB8; -.
DR   SMR; B2TIB8; -.
DR   EnsemblBacteria; ACD22307; ACD22307; CLL_A1818.
DR   KEGG; cbk:CLL_A1818; -.
DR   PATRIC; fig|935198.13.peg.1764; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001195; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..672
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096642"
FT   REGION          443..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..469
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   672 AA;  76091 MW;  F966F3431B458C62 CRC64;
     MKRINILNED TANKIAAGEV VERPASVVKE LVENAIDANS KNILIEIEEG GSSLIRIIDD
     GDGIYKEDIE KAFLPHATSK IKESEDIYSI NTLGFRGEAL PSIASVARVN LKTKQETEEC
     GYEITIEGGK FSEVTECGVN KGTIMEVRDL FFNVPARKKF LKTTSKESSL INDIITRIAL
     SNPNISFKLF NNGKKIIHTY GNGNMKDVIR TIYGKSIVEN VLYFEDTSDI ATIYGYVGKE
     AIARGSRNNQ SIFVNSRYIK NRSLGIAVEQ AFKSFSTVSK FPFFILFIEI YPEYIDVNIH
     PTKSEVKFND ERFIFKKIFG AVHTSLKEEV FSTFSIPEEV NEAISKNTNL NIEEITFKIE
     EEQEKVKFNT NHLSQKNICS TQGNNSINKH IYDEKHKTDT NIPLNVNIPV DLKSDHIKLE
     DDNNSIPNKE VICDNNEVKY ESSYTSDSNQ YENSCKSDVD KESKSKTTGT SELVKEKIPK
     FPAIKIIGQY NKTYILGEYA GTLYMIDQHA AHEKIMFEKY LNDIICGDII IQPLMIPTVI
     DLSMDDYSYF EENKDVFKEA GFTIEDFGGT SIALKEVPYF LGKLKPKNLF LEILDNLKNL
     GSGKTTEVKY NAIATKACKS AVKGNDSLDE LEMVKLIEEL RYIDDPFHCP HGRPTIIQFT
     STDIDKKFRR IV