ID   MUTL_CLOBJ              Reviewed;         666 AA.
AC   C1FNT8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CLM_1956;
OS   Clostridium botulinum (strain Kyoto / Type A2).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=536232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kyoto / Type A2;
RA   Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C.,
RA   Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.;
RT   "Genome sequence of Clostridium botulinum A2 Kyoto.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001581; ACO83413.1; -; Genomic_DNA.
DR   RefSeq; WP_003358879.1; NC_012563.1.
DR   AlphaFoldDB; C1FNT8; -.
DR   SMR; C1FNT8; -.
DR   STRING; 536232.CLM_1956; -.
DR   EnsemblBacteria; ACO83413; ACO83413; CLM_1956.
DR   KEGG; cby:CLM_1956; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001374; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..666
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192166"
SQ   SEQUENCE   666 AA;  76078 MW;  0A2E5DCC91826BEA CRC64;
     MRKINLLDLE TTNKIAAGEV IERPFSVVKE LVENSIDAGA KNITIEIEDG GQNLIKIIDD
     GEGIYPIDIK NAFLPHATSK INSIEDIYKI STMGFRGEAL ASISSVSKTK LKSRVDSYNF
     GKEIYIEGGK IEYLKDTGCN VGTTIEVSDL FYNVPARLKF LKSARSDSSS ISDIVNRFIL
     AHPDISFNLI NKGKQSIKSY GTGNLKDSIR CVYNKTISEN LINFESHKDI ISVYGFIGKP
     EISRKSRTNQ SIFVNKRYVK SKFITAAVEN AFKSFLTVNS YPFFVIFIDI FPEYIDVNVH
     PTKSEVKFKD ERAMFKTIFD AVHEAIKGEL KESFTNFFNK EDINMYDSEK SIAETIKLEK
     EEVQIPIDLN SNNKIDIFGN NINKLPNNAE LLKNIGIKEK NTLENNNNFY TSKQNEICYT
     NKNDECLNSC NKDDYSKIEK PLQKDNKNLD ALYLNEHNTN SSPINIKENK PNNFYVDMKI
     IGQFNNTYIL IEKDKELYII DQHAAHEKVL FEKFKSEIEK GYVISQILLS PVVIELSEDE
     FNIYEENKDI FKNSGFSVET FGECTINIKE VPLILGKPNV EDLFMDILYN LKNMKSKETS
     TIKYNAIATL ACKSAVKAND NLKEEEIKKL IENMLTLNNP YTCPHGRPTM IKFTLKDLEK
     KFKRIQ