ID   MUTL_CLOBK              Reviewed;         666 AA.
AC   B1IM67;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CLD_2841;
OS   Clostridium botulinum (strain Okra / Type B1).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=498213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Okra / Type B1;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000939; ACA46672.1; -; Genomic_DNA.
DR   RefSeq; WP_003403088.1; NC_010516.1.
DR   AlphaFoldDB; B1IM67; -.
DR   SMR; B1IM67; -.
DR   EnsemblBacteria; ACA46672; ACA46672; CLD_2841.
DR   KEGG; cbb:CLD_2841; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000008541; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..666
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096643"
SQ   SEQUENCE   666 AA;  76158 MW;  82AF096D4E502C2A CRC64;
     MRKINLLDLE TTNKIAAGEV IERPFSVVKE LVENSIDAGA KNITIEIEDG GQKLIKIIDD
     GEGIYPIDIK NAFLPHATSK INSIEDIYKI STMGFRGEAL ASISSVSKTK LKSRVDSYNF
     GKEIYIEGGK IEYLKDTGCN VGTTIEVSDL FYNVPARLKF LKSARSDSSS ISDIVNRFIL
     AHPDISFNLI NKGKQSIKSY GTGNLKDSIR CVYNKTISEN LINFESHKDI ISVYGFIGKT
     EISRKSRTNQ SIFVNKRYVK SKFITAAVEN AFKSFLTVNS YPFFVIFIDI FPEYIDVNVH
     PTKSEVKFKD ERAMFKTIFD AVHEAIKGEL KESFTNFFNK EDINIYDSEK SITEPIKLEK
     EEVQIPIDLN SNNKIDIFGN NINKLPNNTE LLKNIGVKAK NTLENNNDFY TSKQNEIYYA
     NKNDECLNSC NKDNYSKIEK SLQKDNKNPD TLYLNEHNTN SSSINIKENK PNNFYVDMKI
     IGQFNNTYIL IEKDKELYII DQHAAHEKVL FEKFKSEIEK GYVISQILLS PVVIELSEDE
     FNIYEENKDI FKNSGFSVET FGEYTINIKE VPLILGKPNV ENLFMDILYN LKNMKSKETS
     TIKYNAIATL ACKSAVKAND NLKEEEIKKL IEDMLILNNP YTCPHGRPTM IKFTLKDLEK
     KFKRIQ