ID   MUTL_CLOBL              Reviewed;         666 AA.
AC   A7GE44;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CLI_1794;
OS   Clostridium botulinum (strain Langeland / NCTC 10281 / Type F).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Langeland / NCTC 10281 / Type F;
RA   Brinkac L.M., Daugherty S., Dodson R.J., Madupu R., Brown J.L., Bruce D.,
RA   Detter C., Munk C., Smith L.A., Smith T.J., White O., Brettin T.S.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000728; ABS39872.1; -; Genomic_DNA.
DR   RefSeq; WP_012099792.1; NC_009699.1.
DR   AlphaFoldDB; A7GE44; -.
DR   SMR; A7GE44; -.
DR   EnsemblBacteria; ABS39872; ABS39872; CLI_1794.
DR   KEGG; cbf:CLI_1794; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002410; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..666
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010006"
SQ   SEQUENCE   666 AA;  76229 MW;  0F47016763FCBFE9 CRC64;
     MRKINLLDLE TTNKIAAGEV IERPFSVVKE LVENSIDAGA KNITIEIEDG GQKLIKIIDD
     GEGIYPIDIK NAFLPHATSK INSIEDIYKI STMGFRGEAL ASISSVSKTK LKSRVDSYNF
     GKEIYIEGGK IEYLKDTGCN VGTTIEVSDL FYNVPARLKF LKSARSDSSS ISDIVNRFIL
     AHPDISFNLI NKGKQSIKSY GTGNLKDSIR CVYNKTISEN LINFESHKDI ISVYGFIGKP
     EISRKSRTNQ SIFVNKRYVK SKFITAAVEN AFKSFLTVNS YPFFVIFIDI FPEYIDVNVH
     PTKSEVKFKD ERAMFKTIFD AVHGAIKGEL KESFTNFFNK EDINIYDSEK SITEPIKLEK
     EEVQIPIDLN SNNKIDIFGN NINKLSNNTE LLKNIGIKEK NTLENNNDFY TSKQNEIYYA
     NKNDECLNSC NKDNYSKIEK SLQKDNKNPD TLYLNEHNTN SSSINIKENK PNNFYVDMKI
     IGQFNNTYIL IEKDKELYII DQHAAHEKVL FEKFKSEIEN RYVISQILLS PVVIELSEDE
     FNIYEENKDI FKNSGFSVET FGEYTINIKE VPLILGKPNV ENLFMDILYN LKNMKSKETS
     TIKYNAIATL ACKSAVKAND NLKEEEIKKL IEDMLILNNP YTCPHGRPTM IKFTLKDLEK
     KFKRIQ