ID   MUTL_CLOBM              Reviewed;         666 AA.
AC   B1KSA2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CLK_1180;
OS   Clostridium botulinum (strain Loch Maree / Type A3).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=498214;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Loch Maree / Type A3;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000962; ACA56562.1; -; Genomic_DNA.
DR   RefSeq; WP_012344415.1; NC_010520.1.
DR   AlphaFoldDB; B1KSA2; -.
DR   SMR; B1KSA2; -.
DR   EnsemblBacteria; ACA56562; ACA56562; CLK_1180.
DR   KEGG; cbl:CLK_1180; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000722; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..666
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096644"
SQ   SEQUENCE   666 AA;  76109 MW;  26E96AA02C32B329 CRC64;
     MRKINLLDLE TTNKIAAGEV IERPFSVVKE LVENSIDAGA KNITIEIEDG GQKLIKIIDD
     GEGIYPIDIK NAFLPHATSK INSIEDIYKI STMGFRGEAL ASISSVSKTK LKSRVDSYNF
     GKEIYIEGGK IEYLKDTGCN VGTTIEVSDL FYNVPARLKF LKSARSDSSS ISDIVNRFIL
     AHPDISFNLI NKGKQSIKSY GTGNLKDSIR CVYNKTISEN LINFESHKDI ISVYGFIGKP
     EISRKSRTNQ SIFVNKRYVK SKFITAAVEN AFKSFLTVNS YPFFVIFIDI FPEYIDVNVH
     PTKSEVKFKD ERAMFKTIFD AVHEAIKGEL KESFTNFFNK EDINIYDSEK SIAETIKLEK
     EEVQIPIDLN SNNKIDIFGN NINKLPTNTE VLKNIGIKEK NILENNDNFY TSKQNEIYYT
     NKNDEYLNSC NKDDYSKIEK PLQKGNKNPD ALYLNEHNTN SSSINIKENK SNNFYVDMKI
     IGQFNNTYIL IEKDKELYII DQHAAHEKVL FEKFKSEIEK GYVISQILLS PVVIELSEDE
     FNIYEENKDI FKNSGFAVEN FGESTINIKE VPLILGKPNV ENLFMDILYN LKNMKSKETS
     TIKYNAIATL ACKSAVKAND NLKEEEIKKL IEDMLILNNP YTCPHGRPTM IKFTLKDLEK
     KFKRIQ