ID   MUTL_CLONN              Reviewed;         645 AA.
AC   A0Q0M7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=NT01CX_2106;
OS   Clostridium novyi (strain NT).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=386415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NT;
RX   PubMed=17115055; DOI=10.1038/nbt1256;
RA   Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X.,
RA   Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B.,
RA   Zhou S.;
RT   "The genome and transcriptomes of the anti-tumor agent Clostridium novyi-
RT   NT.";
RL   Nat. Biotechnol. 24:1573-1580(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000382; ABK60555.1; -; Genomic_DNA.
DR   RefSeq; WP_011722179.1; NC_008593.1.
DR   AlphaFoldDB; A0Q0M7; -.
DR   SMR; A0Q0M7; -.
DR   STRING; 386415.NT01CX_2106; -.
DR   EnsemblBacteria; ABK60555; ABK60555; NT01CX_2106.
DR   KEGG; cno:NT01CX_2106; -.
DR   PATRIC; fig|386415.7.peg.1211; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008220; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..645
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010007"
SQ   SEQUENCE   645 AA;  73302 MW;  084A8EEF2E50FDC8 CRC64;
     MKRINVLSEE TSNKIAAGEV VERPASVVKE LVENSIDANA KNITIEIKES GKDSIKISDD
     GIGIHPNDIE KAFMPHGTSK ISLIEDLYSI NTFGFRGEAL PSIAAVSNVL LKSKTMDSDF
     GKEILVSGGR INHIKDTACN IGTVISVENL FFNVPAREKF LKSDRRESSL ISNIINRLAL
     ANHNISFKYY TNNKKTLMTY ASSDVKNTIR SIYGKNIYEN IISFEEHSDI VSVYGYIGNS
     EISRGSRNNQ SIFVNKRYIK SGTITAAVEN AFKSFSTVNK FPFFVLFVDI YPEFIDVNVH
     PTKSEVKFQD ERIIYKVVFD AVHSALSTSI KESFNINKDS IFDDKDTTYN LIQDETPKQE
     QVQIPIDLQN KRSDSIIENL PKFNPNVSYE KPKDSCRENC LNSIDINLKN TTEELKTKDI
     YYENSISASP KDNILCEKSQ SKNIDNYNTI EAKFPRLNIL GQFNKTYILA ESLDTFYMID
     QHAAHEKILF EKFKNQIENR DVISQILLTP VIIEMSAEDF AYYSENINIF HESGFVTEVF
     GDNIISIREA PMLLGKVSTK DFFLEIFDDI KNMGNGNIAK IKHNMISSLA CKAAIKANHT
     LSYEEMNSLI EDLRYIEEPF NCPHGRPTII KLTLKEIEKK FKRIQ