MUTL_CLOPE
ID MUTL_CLOPE Reviewed; 674 AA.
AC Q8XL86;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CPE1156;
OS Clostridium perfringens (strain 13 / Type A).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=195102;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A;
RX PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; BA000016; BAB80862.1; -; Genomic_DNA.
DR RefSeq; WP_011010290.1; NC_003366.1.
DR AlphaFoldDB; Q8XL86; -.
DR SMR; Q8XL86; -.
DR STRING; 195102.gene:10490419; -.
DR EnsemblBacteria; BAB80862; BAB80862; BAB80862.
DR KEGG; cpe:CPE1156; -.
DR HOGENOM; CLU_004131_4_1_9; -.
DR OMA; AHERIMY; -.
DR Proteomes; UP000000818; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..674
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_0000177941"
SQ SEQUENCE 674 AA; 77206 MW; 2380566BB4500A3D CRC64;
MNRINILNAD TANKIAAGEV VERPSSVVKE LVENSLDAGA KNITIEIQNG GESLIKIIDD
GSGVHPEDVE KAFNPHATSK IKDTYDIFSI NTLGFRGEAL PSIASIARVD FKSKTEDFDM
GKELIISGGE KESLTDCSMN RGTQIEVRDL FFNVPARKKF LKTTARESAL INDLVNRISL
ANPDVSFKLF NNNKKILNTY GNGKLIDVIR TIYGKSTAEN LIYFEEHKDT ASVYGFIGND
TLARASRNNQ SLFVNKRYVK NRSLTVAVEN AFRSFNVTGK FPFFVLFIDT YPELIDVNIH
PTKSEIKFKD ERFIFKVVFD AVHSAMREYV KDTFTLPEEE EKKFEALKEE VIQESLDKEI
STLEKLKENI NYKVSEDKKK EEIYSYNPSK DYEAKTEVNI PVDFLSKENQ DESFSINNSL
ENNEFKEVSA KREISYDPIL IKNELKDKVS ESTSESLERS DYKCNKNEYG NSIEEIIYRE
AKFPKLRVIG QFNKTYILAE YDSTLYLIDQ HAAHEKILFE KYSSDIAKKK VEIQPLMIPL
VVTLPTEDYL YYDENKEIFE KAGFKISDFG DNSIRIEEVP YFLDKLNPTE LITSMINNLK
KMGTGETVEV KYNKIASMSC RAAVKANDVL SILEMENLIE DLRYINDPFH CPHGRPTIIK
FTSYELDKKF KRIT