ID   MUTL_CLOPS              Reviewed;         674 AA.
AC   Q0STR3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CPR_1172;
OS   Clostridium perfringens (strain SM101 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=289380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM101 / Type A;
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA   Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA   Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA   Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA   Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA   Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT   Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000312; ABG85618.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0STR3; -.
DR   SMR; Q0STR3; -.
DR   EnsemblBacteria; ABG85618; ABG85618; CPR_1172.
DR   KEGG; cpr:CPR_1172; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001824; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..674
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010009"
SQ   SEQUENCE   674 AA;  77295 MW;  7709E2733FB03BB2 CRC64;
     MNRINILNAD TANKIAAGEV VERPSSVVKE LVENSLDAGA KNITIEIQNG GESLIKIIDD
     GSGVHPEDVE KAFNPHATSK IKDTYDIFSI NTLGFRGEAL PSIASIARVD FKSKTEDFDM
     GKELIISGGE KESLTDCSMN RGTQIEVRNL FFNVPARKKF LKTTARESAL INDLVNRISL
     ANPDVSFKLF NNNKKILNTY GNGKLIDVIR TIYGKSTAEN LIYFEEHKDT ASVYGFIGND
     TLARASRNNQ SLFVNKRYVK NRSLTVAVEN AFRSFNVTGK FPFFVLFIDT YPELIDVNIH
     PTKSEIKFKD ERFIFKLVFD AVHSAMREYV KDTFTLPEEE EKKFEALKEE VIQESLDKEI
     STLEKLKENI NYKVSDDKRK EEIYSYNPSK DYEAKTEVNI PVDFLSKENQ EESSKFNNSL
     ENNDFKEVSA KREISYDPIL IKNELKDKVS ENTYDSLESS DYKCNKNEYG NSLEERIYRE
     AKFPKLKVIG QFNKTYILAE YDSTLYLIDQ HAAHEKILFE KYSSDIAKKK VEIQPLMIPL
     VVTLPTEDYL YYDENKEIFE KAGFKISDFG DNSIRIEEVP YFLDKLNPTE LIISMINNLK
     KMGTGETVEV KYNKIASMSC RAAVKANDVL SILEMENLIE DLRYINDPFH CPHGRPTIIK
     FTSYELDKKF KRIT