ID   MUTL_CLOTE              Reviewed;         620 AA.
AC   Q895H3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CTC_01301;
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88;
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA   Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA   Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT   disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE015927; AAO35867.1; -; Genomic_DNA.
DR   RefSeq; WP_011099529.1; NC_004557.1.
DR   AlphaFoldDB; Q895H3; -.
DR   SMR; Q895H3; -.
DR   STRING; 212717.CTC_01301; -.
DR   EnsemblBacteria; AAO35867; AAO35867; CTC_01301.
DR   GeneID; 64179095; -.
DR   KEGG; ctc:CTC_01301; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001412; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..620
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010010"
SQ   SEQUENCE   620 AA;  70412 MW;  A9259DF093660957 CRC64;
     MKRINILDEC TFNKIAAGEV VERPFSVVKE LVENSIDAEA KNITVEVKNG GQDLIKVSDD
     GAGIYADDIQ KAFLTHATSK ILNIDDIFSL NTMGFRGEAL PSIASISKIL LKSKPLSETS
     GKEIYMEGGN FISFNDVGMN TGTTIKVTDL FYNVPARLKF LKSSSRESSL ISDIIQRLSL
     ANPDIAFKLI NNGKTVLNTY GSGNLEDAIR VIYGKKTLEN ISYFESHSDI ISVYGYIGNA
     ELSRGSRNNQ SIFVNKRYIK SGLITAAVEN AFKSFLTINK FPFFVIFIDI FPEYIDVNVH
     PTKTEIKFKE DKIVFSFVFK TVHESIKKSL YKEFNEQIKE DVKEDNKEII KENPSLFQNV
     EKVQIPIDLK SASMDIERKS LVNSVLCNEN NIVKDNINKN IYIDTKENLS ENKLKNILKE
     NTEDMVSKLP DMKIIGQFDN TYILAESVKN LYIIDQHAAH EKILFETYRD KIKKDEVKSQ
     LLLQPIVLEL DSEDFSYYVD NKELFYKTGF NIEVFGENTI NIREVPFIMG KPDINNLFMD
     IINNIKAMGS GETIEVKYDS IAMLACKSAV KAHDKLSKEE MEALINDLRF AKDPFNCPHG
     RPTIIKITSL ELEKKFKRIQ