ID   MUTL_COLP3              Reviewed;         652 AA.
AC   Q48A24;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CPS_0323;
OS   Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio
OS   psychroerythus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Colwelliaceae; Colwellia.
OX   NCBI_TaxID=167879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=34H / ATCC BAA-681;
RX   PubMed=16043709; DOI=10.1073/pnas.0504766102;
RA   Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X.,
RA   Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M.,
RA   Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A.,
RA   Zhou L., Davidsen T.M., Wu M., Huston A.L., Lewis M., Weaver B.,
RA   Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.;
RT   "The psychrophilic lifestyle as revealed by the genome sequence of
RT   Colwellia psychrerythraea 34H through genomic and proteomic analyses.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000083; AAZ26944.1; -; Genomic_DNA.
DR   RefSeq; WP_011041196.1; NC_003910.7.
DR   AlphaFoldDB; Q48A24; -.
DR   SMR; Q48A24; -.
DR   STRING; 167879.CPS_0323; -.
DR   EnsemblBacteria; AAZ26944; AAZ26944; CPS_0323.
DR   KEGG; cps:CPS_0323; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; RMASTHA; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000547; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..652
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000071504"
FT   REGION          357..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          425..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  72237 MW;  C2BF32FD84265FD3 CRC64;
     MTIAILPARL ANQIAAGEVV ERPASVIKEL IENSLDAGAT SIHIDVDKGG IKKIKITDNG
     HGIVKEELTL ALSRHATSKI KSLNDLEAIG SLGFRGEALA SISSVARLTL TSKPQSQATA
     WQAVAEGRDM SVNIKPAAHP DGTSIEVLDL FFNTPARRKF LRTEKTEFNH IDEVVRRIAL
     AHFEVSFSLT HNGNTVRQYR MASTHAQCIK RVAMVCGPKF IEHAVEVDCP HDNMTLSGWL
     AKPSFSRSQN DLCYSYVNGR MMRDKLINHA IRQAYADLLP PDTYPAFVLF LQLDHREVDV
     NVHPSKHEVR FHQSRYVHDF IYSVCHKALT SALAGEELFT TADSDLALVP EQSYSSLGAN
     DRQGSHSSNT PTLNYPSADY IRPLQHVNDA SNSQSTSSYS GYGQQHKTNA ISKIAASNYQ
     ALMTPDKGSS AQVQNTSGSD QASAQKHETT TLQNSTDQSA FLSVHQPGYA LYKTENGVRV
     LSLFKLAKST YGKLVEQSWQ NKTEQSDCPV ECLVSQPLLL PVILSLSEQQ LSFVLAEQEI
     LSNAGIVFIQ QHKNKIQIRQ FPALLREQDV SNALIIIIEE LIEKRSFTEG EALCETNLHQ
     SIGLAMVLAE YDETQADILL RLTKKLFHEQ LSQQLLLNSI PLDLTSHIKT LF