ID   MUTL_COXBN              Reviewed;         574 AA.
AC   A9KE32;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CBUD_1186;
OS   Coxiella burnetii (strain Dugway 5J108-111).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=434922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dugway 5J108-111;
RX   PubMed=19047403; DOI=10.1128/iai.01141-08;
RA   Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D.,
RA   Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E.,
RA   Heinzen R.A.;
RT   "Comparative genomics reveal extensive transposon-mediated genomic
RT   plasticity and diversity among potential effector proteins within the genus
RT   Coxiella.";
RL   Infect. Immun. 77:642-656(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABS76590.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000733; ABS76590.2; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A9KE32; -.
DR   SMR; A9KE32; -.
DR   EnsemblBacteria; ABS76590; ABS76590; CBUD_1186.
DR   KEGG; cbd:CBUD_1186; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000008555; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..574
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076694"
SQ   SEQUENCE   574 AA;  64572 MW;  D3775C6D3E7DFE15 CRC64;
     MYIRRLNDQT ANQIAAGEVV ERPASVVKEL IENSIDAHAS CIRVDILQGG AKQIRIQDDG
     DGIHPEDLVL ALERHATSKI AKIDDLQDIT TLGFRGEALA SISAVSRLTL TSRQKNAEMG
     YRISNISHKI MTPVPAAHPQ GTTIDVQDLF YNTPARRKFL RSPATEFQHI RRIIERLALS
     HFTTEFLLHH NEKEIIHFKS ATTISGQENR IKSILGDVFM QSALAIEFSQ SGLTLKGYIA
     EAAYTRSQPD LQYIYVNGRF VRDKLIAQAL RQAYHDVLFH GRHPAYVLYL EIDPAFVDIN
     VHPTKHEVRF RDPQWVRDFL IHAVKTALAQ AKPGIAHPLP QSTAEYNPIT NFAPTPLIEG
     QGNLSLIQEQ PAPYTQTIVH KHPLGHALAQ LQGIYILSQN EKGLVIVDMH AAHERILYEK
     MKKQLAEVGL AMQSLLVPIN LSLNPQEITA WQTNKALFAR LGFEIESFGP DKIVVRRHPS
     LLKPKNLENL IRDVLADLIT HNTTSRVGER INAALATLAC HAALRAPHYL TIEEMEALLR
     EMEKTEHGGL CNHGRPTWKQ FDIAELDTFF LRGQ