MUTL_COXBR
ID MUTL_COXBR Reviewed; 574 AA.
AC A9NCK3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN OrderedLocusNames=COXBURSA331_A0845;
OS Coxiella burnetii (strain RSA 331 / Henzerling II).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=360115;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSA 331 / Henzerling II;
RA Seshadri R., Samuel J.E.;
RT "Genome sequencing of phylogenetically and phenotypically diverse Coxiella
RT burnetii isolates.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000890; ABX78074.1; -; Genomic_DNA.
DR AlphaFoldDB; A9NCK3; -.
DR SMR; A9NCK3; -.
DR KEGG; cbs:COXBURSA331_A0845; -.
DR HOGENOM; CLU_004131_4_2_6; -.
DR OMA; AHERIMY; -.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..574
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000076695"
SQ SEQUENCE 574 AA; 64586 MW; D800E6D67D09B1CC CRC64;
MYIRRLNDQT ANQIAAGEVV ERPASVVKEL IENSIDAHAS CIRVDILQGG AKQIRIQDDG
DGIHPEDLVL ALERHATSKI AKIDDLQDIT TLGFRGEALA SISAVSRLTL TSRQKNAEMG
YRISNISHKI MTPVPAAHPQ GTTIDVQDLF YNTPARRKFL RSPATEFQHI RRIIERLALS
HFTTEFLLHH NEKEIIHFKS ATTISGQENR IKSILGDVFM QSALAIEFSQ SGLTLKGYIA
EAAYTRSQPD LQYIYVNGRF VRDKLVAQAL RQAYHDVLFH GRHPAYVLYL EIDPAFVDIN
VHPTKHEVRF RDPQWVRDFL IHAVKTALAQ AKPGIVHPLP QSTAEYNPIT NFAPTPLIEG
QGNLSLIQEQ PAPYTQTIVH KHPLGHALAQ LQGIYILSQN EKGLVIVDMH AAHERILYEK
MKKQLAEVGL AMQSLLVPIN LSLNPQEITA WQTNKALFAR LGFEIESFGP DKIVVRRHPS
LLKPKNLENL IRDVLADLIT HNTTSRVGER INAALATLAC HAALRAPHYL TIEEMEALLR
EMEKTEHGGL CNHGRPTWKQ FDIAELDTFF LRGQ
