ID   MUTL_DESAP              Reviewed;         565 AA.
AC   B1I293;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Daud_0554;
OS   Desulforudis audaxviator (strain MP104C).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptococcaceae;
OC   Candidatus Desulforudis.
OX   NCBI_TaxID=477974;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP104C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L.,
RA   Hauser L., Kyrpides N., Ivanova N.N., Richardson P.;
RT   "Complete sequence of chromosome of Desulforudis audaxviator MP104C.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000860; ACA59095.1; -; Genomic_DNA.
DR   RefSeq; WP_012301684.1; NC_010424.1.
DR   AlphaFoldDB; B1I293; -.
DR   SMR; B1I293; -.
DR   STRING; 477974.Daud_0554; -.
DR   EnsemblBacteria; ACA59095; ACA59095; Daud_0554.
DR   KEGG; dau:Daud_0554; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_3_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008544; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..565
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096646"
SQ   SEQUENCE   565 AA;  60578 MW;  0261A83F8021AE91 CRC64;
     MARIRVLDAD TVSRIAAGEV VERPAAVVKE LVENALDAGA RVVHIDIAAG GLERITVTDD
     GCGMEPGDAE LALQRHATSK ITAAEDLEAV RTLGFRGEAL PSIAAVSRLT LRTRPAASSA
     GTVLETEGGL VLSAGVSGGP PGTVVTVRDL FFNTPARKKF VRSAAHEGAM ISEMVGRLAL
     SRPEVAFRLT VNGRQVLATS GSGDLLDAIG AVFGAAVARE MVPVRFEERG LGVSGYVGRP
     GVSRSSRRHQ VFFVNGRYIR SAYLGAAAEE SLHGAMPAGR HAVLVLHLSV EPGMVDVNVH
     PAKHEVRFSQ PRDVYVVVHR AVREALHREI QIPVEECGHL ESACFPGAGT GFRIPVQVTF
     QGGEPELREE STGYQGFPQL QPLGFLPPAY ILAGGADGLY ILDQHAAHER VLFEQYLRTL
     EQSAGKQLLV PVMVEIRGRE AQTLEDYGPF LRQAGFEVDP FGEGAYLIRT VPSFLRPGAE
     AVLLTDVLDR LAGERPVDAD AFRRVVAAVL ACHRAVRGGD KPAGPEAAAL LTDLGRCAEP
     YLCPHGRPTL IRIGFPELAR RFQRE