ID   MUTL_DICT6              Reviewed;         575 AA.
AC   B5YE42;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=DICTH_0942;
OS   Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12).
OC   Bacteria; Dictyoglomi; Dictyoglomales; Dictyoglomaceae; Dictyoglomus.
OX   NCBI_TaxID=309799;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35947 / DSM 3960 / H-6-12;
RX   PubMed=24558247; DOI=10.1128/genomea.00109-14;
RA   Coil D.A., Badger J.H., Forberger H.C., Riggs F., Madupu R., Fedorova N.,
RA   Ward N., Robb F.T., Eisen J.A.;
RT   "Complete Genome Sequence of the Extreme Thermophile Dictyoglomus
RT   thermophilum H-6-12.";
RL   Genome Announc. 2:0-0(2014).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001146; ACI18289.1; -; Genomic_DNA.
DR   RefSeq; WP_012546921.1; NC_011297.1.
DR   AlphaFoldDB; B5YE42; -.
DR   SMR; B5YE42; -.
DR   STRING; 309799.DICTH_0942; -.
DR   PRIDE; B5YE42; -.
DR   EnsemblBacteria; ACI18289; ACI18289; DICTH_0942.
DR   KEGG; dth:DICTH_0942; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001733; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..575
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096647"
SQ   SEQUENCE   575 AA;  66585 MW;  F6D95D497BD9C9B9 CRC64;
     MGKVVLLPEE LRNKIAAGEV VERPVSVVKE LVENSIDAGA TRIIVEFANG GETLISVIDD
     GEGMTREDAI LALNRFATSK IKTEEDLYNI KTLGFRGEAL ASIASVSKME LRSKTELEDG
     VFIKVEGGVI KEVNLWQGSK GTVIKVSDLF YNVPARKKFL KSKATETNLI IDFVKRIAIA
     YPQISFQLIQ DGKSKFITPG DGDLENLISL LFDIRVQESL ISFQKREGDY CIEGFVSKPG
     KLIALKSQDY FYVNRRWVRN NTILQAIREG YKGRILDGYF PFSIIFLTVP YSEVDVNVHP
     TKREVKFQKE KEVYEFVFRS IREALDEEEK KFFINMKAPE TESKEYKSDS QITLDREILS
     LPLEFKPYKS EKKLSEAVSE YIPLRSGFRI VGQIFDNYII LETKDKVYII DQHAAHERIK
     YEELKEELNL GYIQNVEILF PVVIEVSEEE KILLDKYKDL LERFAFSWED FGPYHIRIVK
     VPYEFLNFDS KSIENLFREI ISDISEKDLS KLEDKIIKSM ACHSAVRSGN ILIREEMEML
     IKLIFEKNIP LTCPHGRPYI WEISREDLER YFHRR