ID   MUTL_DICTD              Reviewed;         572 AA.
AC   B8E280;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Dtur_1078;
OS   Dictyoglomus turgidum (strain DSM 6724 / Z-1310).
OC   Bacteria; Dictyoglomi; Dictyoglomales; Dictyoglomaceae; Dictyoglomus.
OX   NCBI_TaxID=515635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6724 / Z-1310;
RX   PubMed=28066333; DOI=10.3389/fmicb.2016.01979;
RA   Brumm P.J., Gowda K., Robb F.T., Mead D.A.;
RT   "The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM
RT   6724 reveals a specialized carbohydrate fermentor.";
RL   Front. Microbiol. 7:1979-1979(2016).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001251; ACK42357.1; -; Genomic_DNA.
DR   RefSeq; WP_012583440.1; NC_011661.1.
DR   RefSeq; YP_002352971.1; NC_011661.1.
DR   AlphaFoldDB; B8E280; -.
DR   SMR; B8E280; -.
DR   STRING; 515635.Dtur_1078; -.
DR   EnsemblBacteria; ACK42357; ACK42357; Dtur_1078.
DR   KEGG; dtu:Dtur_1078; -.
DR   PATRIC; fig|515635.4.peg.1114; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_0; -.
DR   InParanoid; B8E280; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000007719; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..572
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192170"
SQ   SEQUENCE   572 AA;  66262 MW;  DFB0E222A7A2F419 CRC64;
     MGKVILLPEE IRNKIAAGEV IERPVSVVKE LVENSIDAGA KRITVEFING GETLISVIDD
     GEGMTKEDAI LALNRFATSK IKTEEDLYNI KTLGFRGEAL ASIASVSKVE VRSKTETEDG
     VFIKVEGGVI QEINLWQGSK GTVIKVFDLF YNVPARRKFL KSKTTETNLI VDFVKRIAMA
     YPEISFQLIQ DGKNKFITSG NGKLEDVVSL LFDIEIHNNL IFLQRKEGNY IIEGFISKPG
     KLISLKSQDY FYVNRRWVRN NIILQAIKEG YKNRLLEGYF PFSIVFLTLP YHEVDVNVHP
     TKREIKFEKE KEVYEFVSKA IKEALDSEDK RFFSGVKALE GKEHKNHVGI KTEKELLSLP
     MEFEHKSENK LSEDISEYIS LKSGFRIVGQ IFDNYIIVET KDRVYIIDQH AAHERIRYEE
     LKKELSLGYL QNVEILFPLV IEVSEEEKEL LNKHKDLLEK FAFSWEDFGP YHIRIIRVPY
     EFLKFDSKSI ENLFQEIISD ISEKDLSKLE DKIIKSMACH SAIRSGNILV REEMEVLINL
     IFERKIPLTC PHGRPYIWEI SKEELERYFH RR