ID   MUTL_EDWI9              Reviewed;         639 AA.
AC   C5BDM9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=NT01EI_0407;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001600; ACR67645.1; -; Genomic_DNA.
DR   RefSeq; WP_015869851.1; NC_012779.2.
DR   AlphaFoldDB; C5BDM9; -.
DR   SMR; C5BDM9; -.
DR   STRING; 67780.B6E78_12810; -.
DR   PRIDE; C5BDM9; -.
DR   EnsemblBacteria; ACR67645; ACR67645; NT01EI_0407.
DR   GeneID; 7961232; -.
DR   KEGG; eic:NT01EI_0407; -.
DR   PATRIC; fig|634503.3.peg.367; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ATQEQAW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..639
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203385"
FT   REGION          336..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   639 AA;  70006 MW;  58144F6857B95DE6 CRC64;
     MPIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
     GGIGKAELAL ALARHATSKI STLDDLEAIV SLGFRGEALA SISSVSRLTM TSRPEGQAEA
     WQAYAEGREM AVMVKPSAHP VGTTVEVLDL FYNTPARRKF LRTEKTEFAH IDEVVRRIAL
     ARFDITLTLQ HNGKTVRQYR AVKEGDARER RLGAICGPVF VQHALALTWR HDELAIHGWV
     AAPQAIRQIG ELQYCYVNGR MMRDRLITHA IRQAYQDRLS DEMPPAYVLY LEIDPRQVDV
     NVHPAKHEVR FHQARLVHDF IYQAVVEVLQ QAQVASAHDD PTPAISGAAR DEEPRGVENR
     ASAGENRFNR PASSPVASAP RPAHVAAPRM PAGDIFRRRE GELYQRLLAA NPAPAAETDS
     AFVAAPGAPV TVAGPPAVAV STAAENGAPG DSFGRVLTLC ADGVALTECR SGVALVSLFH
     ARRCLLRAQL QPPDEGLKAQ PLLVPLRLTL EAAERQALKT QQPLLQQMGL RLQPERQHAL
     LHAVPLPLRQ QNLPRLIPQM LRYLATASVC DAASLADWLA AHWHSADEAP WTVAQAVQLL
     ADLERLCPQL VQSPPRALLQ PLDLQPGVDR LRQEEQLNE