ID   MUTL_EHRCR              Reviewed;         673 AA.
AC   Q2GFV4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=ECH_0884;
OS   Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=205920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC CRL-10679 / Arkansas;
RX   PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA   Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA   Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA   Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C.,
RA   Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D.,
RA   Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA   Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT   "Comparative genomics of emerging human ehrlichiosis agents.";
RL   PLoS Genet. 2:208-222(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000236; ABD45257.1; -; Genomic_DNA.
DR   RefSeq; WP_011452874.1; NC_007799.1.
DR   AlphaFoldDB; Q2GFV4; -.
DR   SMR; Q2GFV4; -.
DR   STRING; 205920.ECH_0884; -.
DR   EnsemblBacteria; ABD45257; ABD45257; ECH_0884.
DR   KEGG; ech:ECH_0884; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008320; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..673
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010014"
SQ   SEQUENCE   673 AA;  76055 MW;  F793F2D42B598228 CRC64;
     MSIILLDPRT INRIAAGEVI ECPASVVKEL VENSIDAKAT AISITIERGG RNLIIVSDNG
     IGIKKEDMEI AFARHATSKL PDGDLTKVRS LGFRGEGLTS IAAVGKVKMV SKYRDSDTAW
     LMVFEGGEKT QELTPDALSC GTYIEVRDLF FATPNRLKFL RTEKAEVQSI IDMMNKLAMV
     NHNVMFSLFV DNKQVFKYLT QQSNIDRLSE IKTLGMEFCK NSLPVNVKEE QIQLSGYIGS
     PTLSRGKSSL IYTFVNSRPV YDNLLIGAVR YAYSDFIEKD KYPVVVLYLD IPCDQVDANV
     HPNKSEVRFQ DKKLVYRTVV NAIKEVLSIN LNTKLKSISE FENDHFVHAS MVNSRNIGNS
     VSSEFFKCFQ NRKPLLNNDV QKYSSKNVET DDQSLLDTNV SFCTDSKMIT NKLKEERVYE
     NSREHINKGD SKIEVSNFDI LGEKKNFVNL ANNLLQESPS IDSGKFNTSK KVPSDSLIDT
     YPLGYALCQI HSRYIISQTQ DSIVIIDQHA AHERLTYEYM KQVMAKEGIK RQILLIPEII
     EMNNHLDLEL LVEYKEKLLK LGLLIEPLGN LSVIVREVPA LFGSFDVKSL IINIVDSIME
     VGDTLFLDDK IKDICGTIAC YSSIRSGRKL KIEEMNAILR NMENTAHSGQ CNHGRPTYVE
     LNLVEIDRLF SRR