MUTL_ELUMP
ID MUTL_ELUMP Reviewed; 608 AA.
AC B2KB18;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Emin_0215;
OS Elusimicrobium minutum (strain Pei191).
OC Bacteria; Elusimicrobia; Elusimicrobia; Elusimicrobiales;
OC Elusimicrobiaceae; Elusimicrobium.
OX NCBI_TaxID=445932;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pei191;
RX PubMed=19270133; DOI=10.1128/aem.02698-08;
RA Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H.,
RA Lapidus A., Hugenholtz P., Brune A.;
RT "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated
RT representative of the phylum 'Elusimicrobia' (formerly termite group 1).";
RL Appl. Environ. Microbiol. 75:2841-2849(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP001055; ACC97777.1; -; Genomic_DNA.
DR RefSeq; WP_012414392.1; NC_010644.1.
DR AlphaFoldDB; B2KB18; -.
DR SMR; B2KB18; -.
DR STRING; 445932.Emin_0215; -.
DR EnsemblBacteria; ACC97777; ACC97777; Emin_0215.
DR KEGG; emi:Emin_0215; -.
DR HOGENOM; CLU_004131_4_2_0; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000001029; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..608
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000096651"
SQ SEQUENCE 608 AA; 67341 MW; CE92E72B709F39A0 CRC64;
MGKIKILEES VAARIAAGEV IERPAGVLKE LLENAVDAGA DTINIDIDGA GKKLIRVNDN
GSGMSKEDLT LSVVRHSTSK IKNFEDLDSL DTFGFRGEAL YSVAAVSKLS ISSAEEGGSG
NKIIVEGGKL ISVSPSPNIK GTTVEVKDLF YNTPARLKFL KSDNYERSLL LKVVEESALA
NLHVSYNVRT DGRLVYSFLA SNGDFKKTVI QRAGQILGAE IAVSLISVED ERFGFKAFLT
PLSKLTAVRD LQFFFINKRP LTSKTLQQAV YKAYHGRPKD RHPAFIVFMN MPAADFDVNI
HPQKRDVKFA QENAVFGFLM NVTQRALTGA AQPVDINITP ASPPAATMEF SFAKPRAEEP
SYKPFGQNIV EENVFAPISK QAVVVKDFED PVSYNPEPAE PKKEMGAHVQ TDNPSWWQGP
YRFLGSLHKS YLIYETELGL MLVDQHAARE RVLYEEYLKK MEENELGIQP LMFPVTVDLP
ASNVENLMLW KDWLKTAGFE IEQFSPRTVL VNAVPNIFRF KEDSLKEFIV SLAGIVGDPL
KSSDELKKKT VAMLACKKSI KAKEDVSMAE ADALLLDLKR CQDGMHCPHG RPVMVSLSAA
ELTKKFGR