ID   MUTL_ENDTX              Reviewed;         595 AA.
AC   B1H0C7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=TGRD_476;
OS   Endomicrobium trichonymphae.
OC   Bacteria; Elusimicrobia; Endomicrobia; Endomicrobiales; Endomicrobiaceae;
OC   Endomicrobium.
OX   NCBI_TaxID=1408204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18391199; DOI=10.1073/pnas.0801389105;
RA   Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T.,
RA   Sakaki Y., Toyoda A., Hattori M., Ohkuma M.;
RT   "Complete genome of the uncultured termite group 1 bacteria in a single
RT   host protist cell.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP009510; BAG13959.1; -; Genomic_DNA.
DR   RefSeq; WP_015423485.1; NC_020419.1.
DR   RefSeq; YP_001956420.1; NC_020419.1.
DR   AlphaFoldDB; B1H0C7; -.
DR   SMR; B1H0C7; -.
DR   STRING; 471821.TGRD_476; -.
DR   EnsemblBacteria; BAG13959; BAG13959; TGRD_476.
DR   KEGG; rsd:TGRD_476; -.
DR   PATRIC; fig|471821.5.peg.769; -.
DR   HOGENOM; CLU_004131_4_1_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001691; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..595
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096698"
SQ   SEQUENCE   595 AA;  67471 MW;  221D916E93E94EB5 CRC64;
     MPINILSQET VNKIAAGEVV ERPLNAVKEL VENSLDAFAS SITVEIEEAG KKLIRVSDNG
     FGMDKKDLEL SILRHATSKI DDFKDLMHIH SLGFRGEALA SIAAVSNFAI KTRKKGENSG
     WKLSVAGAKD IKVMPWSGAE GTITEVKSLF FNTPARQKFL KSDSTERSRI INSLEETALA
     NYDISFKIFS ENKTVFSAAQ TDSKTERIAD ILGKDFAKTL KNIKIDHPKI SLDVYFTGRD
     NSLPNKKYQY LFVNSRPVNY PKRLMHCVYQ SYKESIPRDK YPGILIYTDV DPSEIDVNIH
     PAKREVKFAD ENGIYDILFK ALRNALMSQG HPEIKITYPP LDKEKSAKQE VEGSTAPRFP
     KIQQPVIYAR EPKPKYNYAS LKQTCSIDKY ADVFAKQEEL TPENFDSNIK VIGQVFDTYI
     IASNKGDLYI FDQHAAAERV RYEFYLSQMK SQTIKIQQML MPENFDLSPS ISELLKANIN
     IFNELGISIE EFGQNSFRIT AYPALLGNIS MEQIVKTIIS DIEDDKHAEI EQKRDKIIRS
     ACRASIKAGD NVSFIEAKKL INDLFKCKQP FTCPHGRPTA YKISLNEIEK FFKRK