ID   MUTL_ERWT9              Reviewed;         611 AA.
AC   B2VCU8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=ETA_29690;
OS   Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB
OS   4357 / Et1/99).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=465817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99;
RX   PubMed=18462403; DOI=10.1111/j.1462-2920.2008.01639.x;
RA   Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R.,
RA   Geider K.;
RT   "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic
RT   bacterium in the genus Erwinia.";
RL   Environ. Microbiol. 10:2211-2222(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CU468135; CAO98015.1; -; Genomic_DNA.
DR   RefSeq; WP_012442667.1; NC_010694.1.
DR   AlphaFoldDB; B2VCU8; -.
DR   SMR; B2VCU8; -.
DR   STRING; 465817.ETA_29690; -.
DR   EnsemblBacteria; CAO98015; CAO98015; ETA_29690.
DR   KEGG; eta:ETA_29690; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ATQEQAW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001726; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..611
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096652"
FT   REGION          353..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   611 AA;  67837 MW;  1CEDFE018F5BEB0D CRC64;
     MAIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIEKGG AKLIRIRDNG
     CGIAKDELAM ALARHATSKI TSLDDLEAII SLGFRGEALA SISSVSRLTL TSRTEAQTEA
     WQAYAEGRDQ AVTVKPAAHP VGTTLEVLDL FYNTPARRKF MRTEKTEFTH IDEIIRRIAL
     VRFDVAISLT HNGKLVRQYR AVSDDGQRER RLGAICGTAF LSHALKIDWQ HGELSLHGWV
     ADPSGSKALS ELQYCYVNGR MMRDRLINHA IRQAYEDKLG DRHQPAYVLY LEIDPHQVDV
     NVHPAKHEVR FHQSRLVHDF IYQGVVSVLQ ESGAETLPEI ATAQPAERWQ PENRQAAGGN
     HFATPAPAAA PRPASTASSS WQRQEPVYQK REGAAYQQLL QTPTRSEEPP LSPASVTQND
     APALSAHAQS FGRVLTIVRE QYALLEGKKG LALLALTVAE RWLKQAQLEP GSEGLRPQPL
     LIPVRLKLDK AERDAGNRCS ELLNQMGIDL KFDAHHVMLR AVPLPLRQQN LQNLIPEMLG
     YLAQHQDVTA FQLAQWFARQ SASEHQHWNH SQAITLLAEV ERLCPTLVKS PPSGLLQNVD
     IEMAMNALKH E