MUTL_EXISA
ID MUTL_EXISA Reviewed; 605 AA.
AC C4L192;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=EAT1b_0104;
OS Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b).
OC Bacteria; Firmicutes; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium;
OC unclassified Exiguobacterium.
OX NCBI_TaxID=360911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1283 / AT1b;
RX PubMed=21460088; DOI=10.1128/jb.00303-11;
RA Vishnivetskaya T.A., Lucas S., Copeland A., Lapidus A., Glavina del Rio T.,
RA Dalin E., Tice H., Bruce D.C., Goodwin L.A., Pitluck S., Saunders E.,
RA Brettin T., Detter C., Han C., Larimer F., Land M.L., Hauser L.J.,
RA Kyrpides N.C., Ovchinnikova G., Kathariou S., Ramaley R.F., Rodrigues D.F.,
RA Hendrix C., Richardson P., Tiedje J.M.;
RT "Complete genome sequence of the Thermophilic Bacterium Exiguobacterium sp.
RT AT1b.";
RL J. Bacteriol. 193:2880-2881(2011).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP001615; ACQ69038.1; -; Genomic_DNA.
DR RefSeq; WP_012726157.1; NC_012673.1.
DR AlphaFoldDB; C4L192; -.
DR SMR; C4L192; -.
DR STRING; 360911.EAT1b_0104; -.
DR EnsemblBacteria; ACQ69038; ACQ69038; EAT1b_0104.
DR KEGG; eat:EAT1b_0104; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_9; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000000716; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..605
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000203387"
SQ SEQUENCE 605 AA; 68652 MW; 2E3CAD1666D6CB68 CRC64;
MGIIRELPEQ LANRIAAGEV VERPASVVKE LVENAIDAGA TKVDVDLQEA GIRLIKVRDN
GHGFHEEDAA RAFLRHATSK IRDEHDLFRI RTLGFRGEAL ASIASVSHVL LKSKRADEDG
FEMTLEGGVV KETNPTATNV GTEIAVSQLF FNTPARLKYL KTSATELASI TDTLNRLALS
HPEIRFTVFH EEKELLRTNG NGDLKQVMLA IYGRQVAAQI VTASSKTSDY TLSAHLVRPE
VTRSNKQYVT LILNGRSIKN FALTQSVLEG YHTLLPIGRY PIAVLEVKMD PMLIDVNVHP
TKREVRLSKE KELCQLIRET VQLTLREQRL IPSVKQEPKL KRVTPSEQSK LDFSMEPQPK
QADSVEWNYP IPRERKETLT SPSQWNPAPL VHEPEAEMIE PEQVEESVRQ SERLPALDVI
GQLHSSYIIC GAEDGMYVMD QHAAQERIKY ELFYEQLGRP EKEYQLLLIP LTLEFTQEET
LAIEEVLPLL AEAGITLEPF GGNTFLVREI PTWYPQHDLE GTIRDLVEMA IQQRSIDIAK
YREEASILMA CKRSIKANHP LNMEMMRQLI DDLSRTTSPF TCPHGRPILV KWSTYELEKL
FKRVM