ID   MUTL_FERNB              Reviewed;         588 AA.
AC   A7HNR3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Fnod_1711;
OS   Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1).
OC   Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC   Fervidobacterium.
OX   NCBI_TaxID=381764;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35602 / DSM 5306 / Rt17-B1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Fervidobacterium nodosum Rt17-B1.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000771; ABS61546.1; -; Genomic_DNA.
DR   RefSeq; WP_011994837.1; NC_009718.1.
DR   AlphaFoldDB; A7HNR3; -.
DR   SMR; A7HNR3; -.
DR   STRING; 381764.Fnod_1711; -.
DR   EnsemblBacteria; ABS61546; ABS61546; Fnod_1711.
DR   KEGG; fno:Fnod_1711; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002415; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..588
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192179"
SQ   SEQUENCE   588 AA;  67371 MW;  782E867674288878 CRC64;
     MSVIKKLPQE VVSKIAAGEV VINPASVVKE LVENSLDANA TSIEVQIRNG GKSYIKVSDN
     GIGMSRDDML IAIDRFTTSK ISALEDIYNI HSYGFRGEAL SSIAEVSRLI ITSSDGNNAH
     RLEVIGGKII KITETHRERG TTVEVYDLFF NIPARRKFLS SEKVETRMVT EIVEKFMLVQ
     PSVSFVFKIE DEIVYNASKG SLEDRFSIIF PEVKEFSLIE PLQSEIMQIS GIISSPQYTR
     RNRSGQIFFV NKRFVIDNLL NLSFERGYGE ALAQGEHPYG VIFLDFLPDK IDVNIHPQKL
     QVKFSDPQNV YNEIARTIRT TLRKFSFFQM SISKNSEEEE KYSSEISNQN LKAENYQHTD
     SEWYPNQFKN LYQKETPQTY RPYEPLSSIS QNLLLPQLNE KSLPKEFIVL KDRYIVFEDL
     DGLVIIDFHA AHERIIYEQL KENKFETVQL LIPLHIKLGK SFLQLSQQLT DEFKKYGFDF
     EIKTLEDGSG EVVIKQIPSI LKVTDASNVF LEVLEEYRIP FEKPKGLTYV LASKACKSAV
     KTGDKLSHDE VQQIIKEIKS KNLLTCPHGR PIMMKLSFSQ LDSFFERI