MUTL_FLAJ1
ID MUTL_FLAJ1 Reviewed; 644 AA.
AC A5FNH2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Fjoh_0211;
OS Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC
OS 14942 / NCIMB 11054 / UW101) (Cytophaga johnsonae).
OC Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=376686;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101;
RX PubMed=19717629; DOI=10.1128/aem.01495-09;
RA McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G.,
RA Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R.,
RA Cheng Y.Q., Stein J.L.;
RT "Novel features of the polysaccharide-digesting gliding bacterium
RT Flavobacterium johnsoniae as revealed by genome sequence analysis.";
RL Appl. Environ. Microbiol. 75:6864-6875(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000685; ABQ03248.1; -; Genomic_DNA.
DR RefSeq; WP_012022319.1; NZ_MUGZ01000005.1.
DR AlphaFoldDB; A5FNH2; -.
DR SMR; A5FNH2; -.
DR STRING; 376686.Fjoh_0211; -.
DR EnsemblBacteria; ABQ03248; ABQ03248; Fjoh_0211.
DR KEGG; fjo:Fjoh_0211; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_10; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000006694; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..644
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000076697"
FT REGION 363..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 71506 MW; AE49AEA2EAEA5F68 CRC64;
MSSIIQLLPD HVANQIAAGE VVQRPASVVK ELLENAVDAK ATDIKLIIKD AGKSLVQVID
NGVGMTVTDA RLCFARHATS KIRQAEDLFS LGTKGFRGEA LASIAAIAHM EMKTKQEQDE
LGTHIVIEGS KFVSQEVAVL PKGTSFAVKN LFFNIPARRN FLKSDTVEFR HVMDEFQRVA
LAHPNIHFSF YHNGSELYNL PAAGYRQRIV GIMSGKTNEK LVPVNEDTEI ISIQGFVCKP
EFAKKNRGEQ FFFVNDRFIK SGYLHHAVMA AYDGLLKDGS QPSYFLYLQV PPNTIDINIH
PTKTEIKFDD EQALYAILRA SIKHSLGQFN VAPVLDFDRD SNLDTPYHYK DVEAEVPTIQ
VDGTFNPFTD DKTNQHYTKA GSGSGSGYSS GSSSSSGSGS GSSYSGYSKR VEPTVSWESL
YVGLDTENPE TIESSPFIFE NEEVTSSLFN DDEVEQASQK TYQIHKKYIV SPIKSGMVIV
DQHRAHQRIL YEQFLLNMTV NQASSQQLLF PLDLFYSSSE MKLIEELKPS LETTGFVFEE
AQTDHVVISG IPVNITESEV SLVIEQLLSD LQDGIPASSY SQNDTIAKSM AKSLAVKTGS
YLTEKEQDNL VNGLFACKDP NISPFQKPTF ITMRVEDIDK KFAL