ID   MUTL_FLAPJ              Reviewed;         613 AA.
AC   A6GYR1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=FP1147;
OS   Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS   JIP02/86).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=402612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86;
RX   PubMed=17592475; DOI=10.1038/nbt1313;
RA   Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B.,
RA   Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F.,
RA   Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT   "Complete genome sequence of the fish pathogen Flavobacterium
RT   psychrophilum.";
RL   Nat. Biotechnol. 25:763-769(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AM398681; CAL43234.1; -; Genomic_DNA.
DR   RefSeq; WP_011963285.1; NC_009613.3.
DR   RefSeq; YP_001296045.1; NC_009613.3.
DR   AlphaFoldDB; A6GYR1; -.
DR   SMR; A6GYR1; -.
DR   STRING; 402612.FP1147; -.
DR   EnsemblBacteria; CAL43234; CAL43234; FP1147.
DR   KEGG; fps:FP1147; -.
DR   PATRIC; fig|402612.5.peg.1160; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000006394; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..613
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000058143"
SQ   SEQUENCE   613 AA;  69062 MW;  FA626AAC8C90A9A4 CRC64;
     MSSIIQLLPD HVANQIAAGE VVQRPASVVK ELLENAIDAG ASDIKLICKE AGKVLIQVID
     NGKGMSVTDA RLCFERHATS KIRQAEDLFD LHTKGFRGEA LASIAAIAHV EMKTKQDQEE
     LGTHIIIEGS KFVSQDVAVL PKGTSFLVKN LFFNIPARRN FLKSDIVELR HIIDEFQRVA
     LAHHNIHFTF YHNGSELFNL PQSNVRQRIV NIFSGKTNEK LVPIQENTDI LSIQGFIGKP
     EFAKKSKGEQ FFFVNDRFIK SGYLHHAIMN AYEGLLRDGA QPSYFLYLDV PPHTIDINIH
     PTKTEIKFDD EQALYAILRS ATKHSLGQFN VAPVLDFERD FNLDTPYSYQ NKEAETPTIQ
     VDSNFNPFQE EKKQSNFSYK PKTEKQPHWE SLYVGLDTKS IDLDEMSFES ETVTSSLFSD
     SEVEKAPTTT YQIHKKYIVN PIKSGMLIID QQRAHQRILY EQFLTNITIH QANSQQLLFP
     VTLYFSGNEM ALIQEIKQSL ESTGFVFEAL NKDSIVISGL PVTVSESEAS IVLEQLVSDL
     QQEVPDSSFS QMDSMAKSMA KSLAVKTGTY LTEEAQVNLV NNLFACKEAT VSPFNKTTFI
     TLSVEDLDKK FSI