ID   MUTL_GEMAT              Reviewed;         607 AA.
AC   C1A8L2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GAU_1530;
OS   Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC
OS   100505).
OC   Bacteria; Gemmatimonadetes; Gemmatimonadales; Gemmatimonadaceae;
OC   Gemmatimonas.
OX   NCBI_TaxID=379066;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T-27 / DSM 14586 / JCM 11422 / NBRC 100505;
RA   Takasaki K., Ichikawa N., Miura H., Matsushita S., Watanabe Y., Oguchi A.,
RA   Ankai A., Yashiro I., Takahashi M., Terui Y., Fukui S., Yokoyama H.,
RA   Tanikawa S., Hanada S., Kamagata Y., Fujita N.;
RT   "Complete genome sequence of Gemmatimonas aurantiaca T-27 that represents a
RT   novel phylum Gemmatimonadetes.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP009153; BAH38572.1; -; Genomic_DNA.
DR   RefSeq; WP_012683019.1; NC_012489.1.
DR   AlphaFoldDB; C1A8L2; -.
DR   SMR; C1A8L2; -.
DR   STRING; 379066.GAU_1530; -.
DR   PRIDE; C1A8L2; -.
DR   EnsemblBacteria; BAH38572; BAH38572; GAU_1530.
DR   KEGG; gau:GAU_1530; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_0; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002209; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..607
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203388"
SQ   SEQUENCE   607 AA;  65248 MW;  C785134DC4468A76 CRC64;
     MSRIAILPSA VADQIAAGEV VERPASVVKE LVENALDAGA TSVDITIEDG GRTLIRIADN
     GSGMDGADAV LALSRHATSK ITSAEQLVGV RSFGFRGEAL PAIASVSELQ IETASEDGSG
     TLVRVQAGTL TETGQVARRQ GTTVSVHRLF HNTPARLKFM RSARSEWRAI VDAMQAIGVL
     RRDVHFTVRH DGRVALDWPA VSTLRARLAA LWGAADVERF VDVDDVQGVV HVSGLAERPA
     DVGTATRRVL LIVNGRVVRD HGLIRAAEAA YRSTIPAGMR PSLVLQVHVP GGDVDVNVHP
     AKAEVRFRDR WPLERAVEEA VRRALGLFDA SAGIGWRTWS AAPASREPGH ALGGIPLEPS
     ALRAAPAPEG LFATPAAADA NLAQHAIATA TAPTADDLTS AMQVDAMRAE AAREMETLVV
     PPLMQLRKTY LMFEHDEGVV LIDQHSAHER VLYEQFLGVL ERGEAPSQRL LFPLTLHLGP
     QEADAFEAHR DAFVRLGFEI DHFGGTSLLV QAVPMPHPRF DAERCLRDTL AALIGDRGAS
     AAAKHERLAA TFACKAAIKA GDQMSPGEMQ ALYRALAATV LPAHDVHGRS TIVRLSWDEL
     DRRFGRK