ID   MUTL_GEODF              Reviewed;         598 AA.
AC   B9M3N0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Geob_3108;
OS   Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32) (Geobacter
OS   daltonii).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geotalea.
OX   NCBI_TaxID=316067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22248 / JCM 15807 / FRC-32;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Kostka J., Richardson P.;
RT   "Complete sequence of Geobacter sp. FRC-32.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001390; ACM21451.1; -; Genomic_DNA.
DR   RefSeq; WP_012648179.1; NC_011979.1.
DR   AlphaFoldDB; B9M3N0; -.
DR   SMR; B9M3N0; -.
DR   STRING; 316067.Geob_3108; -.
DR   EnsemblBacteria; ACM21451; ACM21451; Geob_3108.
DR   KEGG; geo:Geob_3108; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000007721; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..598
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192180"
SQ   SEQUENCE   598 AA;  66238 MW;  25D8A100659FD852 CRC64;
     MATRIKILPE QLTNKIAAGE VVERPASVVK ELVENALDAG CSEVMVEIEA GGKRLIRVSD
     TGCGMTREDA LLALERHATS KIANDEDLFS LATLGFRGEA LPSVASVSRF TLATREKGSL
     EGTEIYAEGG RIKEVKACGM AEGTVISVRN LFFNTPARLK FMKSSETEAG HVGDLLTRLA
     ISRPDIRFIY TNDGKTVFRA LNADLRERVA TLLGRTLSQD LYPLDFCDGQ LNVTGLVGKP
     ECSRSAASHV YTYINGRFIR DKVVQHAVLQ AYRNFMERGR YPVVVLFISV PAAEVDVNVH
     PTKHEVRFRE QGRVHDAIQE AVESVLRSSP WVKTQPVVQK TQASTSIAAA RIAQVRESLT
     QYRPQKTTQQ SFKMSTPAVP ASFRETSLPD PVPVADAAPA PEVERGYFSG LSVIGQFNAA
     YILCQDGNSL VIIDQHAAHE RVAFERLKTQ HAAMGVESQR LLFPETVEFS FKEGAVIREH
     QTELDRVGFS LEEFGGSTWL LNAVPHLLSG NDYVKTLRDI LEELQSLGRS RSFQDILEDI
     LARIACHSVV RGSHCLSQQE IKALFQQMDT TEFSSNCPHG RPVLHTLTLA EIERMFKR