ID   MUTL_GEOKA              Reviewed;         630 AA.
AC   Q5L0E4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GK1307;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT   Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; BA000043; BAD75592.1; -; Genomic_DNA.
DR   RefSeq; WP_011230806.1; NC_006510.1.
DR   AlphaFoldDB; Q5L0E4; -.
DR   SMR; Q5L0E4; -.
DR   STRING; 235909.GK1307; -.
DR   EnsemblBacteria; BAD75592; BAD75592; GK1307.
DR   KEGG; gka:GK1307; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..630
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010017"
FT   REGION          361..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   630 AA;  70066 MW;  92D939BE304B74C5 CRC64;
     MGRIRKLDDL LANKIAAGEV VERPASVVKE LVENAIDAHS TVINIELEEA GMAKIRVIDN
     GDGMEEDDCL LAFERHATSK IHDEHDLFRI RTLGFRGEAL PSIASVSEVE LTTGTGSGPG
     TKLVLQGGAL VSRERAAGRK GTDITVSNLF FNTPARLKYM KTIHTELGHA ADVVNRLALA
     HPDVSFRLRH QGKTLLATNG SGDVRHVLAA IYGAETARQM IPIEAESLDF TIRGYISPPD
     VTRASRNYIS LVVNGRYVRS VPLMKAIEAG YHTLLPIGRY PIVFLSIEMD PVLVDVNVHP
     AKLEVRFSKE AELNELVTDA IRQAFRKRTL IPSVSADSKM AKPKAEQAAW TFTHRVREPS
     VLSSDIGGGE DATAPLAPLT GDAPAERPSA AVQTDECGIL DEHGPAFERK QEEEVGEERC
     SPRLPTDGQA EDKAAADRLP PLYPIGQLHG TYILAENEHG LYMIDQHAAQ ERINYEYFRE
     KLGEATKEVQ ELLVPLMFEY PADEYERIAA CRDELARCGV FLEPFGPRAF LVRSHPTWFP
     KGREREIIEE MIEQVLAAKT VDIKQLREQA AILMSCKRAI KANQHLRQDE LFALLEALRQ
     TTDPFTCPHG RPIIVHFSTY EIEKLFKRVM