ID   MUTL_GEOSL              Reviewed;         606 AA.
AC   Q74BP0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GSU2001;
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA;
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn M.L., Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J.,
RA   Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A.,
RA   Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E.,
RA   Lovley D.R., Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE017180; AAR35377.1; -; Genomic_DNA.
DR   RefSeq; NP_953050.1; NC_002939.5.
DR   RefSeq; WP_010942644.1; NC_002939.5.
DR   AlphaFoldDB; Q74BP0; -.
DR   SMR; Q74BP0; -.
DR   STRING; 243231.GSU2001; -.
DR   EnsemblBacteria; AAR35377; AAR35377; GSU2001.
DR   KEGG; gsu:GSU2001; -.
DR   PATRIC; fig|243231.5.peg.2037; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   InParanoid; Q74BP0; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..606
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010018"
FT   REGION          377..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..394
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   606 AA;  66598 MW;  AC680F81EA58A0BD CRC64;
     MPHRIRILPE ILTNKIAAGE VVERPASVVK ELVENALDAG CGEIIVEIEG GGRRLIRITD
     DGCGMSREDA LMALERHATS KIATDDDLFS LATLGFRGEA LPSVASVSRF TLATRERGSI
     EGTEIYAEGG KIREVKACGM AEGTVVSVRN LFFNTPARLK FMKSVETEGG HVADLVTRLA
     LSRPEVRFTC VSDGKTLFRA LDGTLLDRVA ALLGKTVASA LHPVDLATEG VRVTGLVARP
     DVSRSAASHL YTYINGRFIR DRVVQHAILQ AYRNFLERGR YPVVVLFIEV SPGEVDVNVH
     PTKHEVRFRQ QGIVHDVIQG AVEETLRLTP WIRRSESPVA APLAVPRPQQ YVQGTGARQV
     EEVRELLENY RPAVAPHRPL FAPQPAPQPD REPPLPDSGS RMLDDTAVRR HGGYFSSLAV
     IGQYNASYIL CQDGSDLVII DQHAAHERVA FERLKTQFAA GRVEGQGLLF PETVELSHRE
     SAVVREHGGE LGRLGFDLED FGGTTWIVKG IPRLLAGTDY LRLLRDTLEE LQSLGASRSI
     ADAVEDILTR VACHSVVRGE HPLTTGEIEA LFAHMDATDF STNCPHGRPV LQRLTLGEVE
     KMFKRV