ID   MUTL_GEOSM              Reviewed;         650 AA.
AC   C6E4L2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GM21_3282;
OS   Geobacter sp. (strain M21).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter; unclassified Geobacter.
OX   NCBI_TaxID=443144;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M21;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Lovley D.;
RT   "Complete sequence of Geobacter sp. M21.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001661; ACT19308.1; -; Genomic_DNA.
DR   RefSeq; WP_015838520.1; NC_012918.1.
DR   AlphaFoldDB; C6E4L2; -.
DR   SMR; C6E4L2; -.
DR   STRING; 443144.GM21_3282; -.
DR   EnsemblBacteria; ACT19308; ACT19308; GM21_3282.
DR   KEGG; gem:GM21_3282; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   OMA; AHERIMY; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..650
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203389"
FT   REGION          358..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..386
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   650 AA;  71197 MW;  15BD58F55171BB0D CRC64;
     MATKIRILPE NLTNKIAAGE VVERPASVAK ELVENALDAG SKEVVVEIES GGRRLIKVSD
     TGCGMSRDDA LLALERHATS KIATDEDLFS LCTLGFRGEA LPSVASVSRL TISTRTSDSV
     EGTEIYAEGG RIKEVKECGM AVGTVISVRN LFFNTPARLK FMKSAETEGG HVGELLTRLA
     ISRPEVRFTY KNDGKVMFRA LDADLKERVA TMLGRSISSF LYPVSYQEGG LKVSGLVAAP
     ECSRSAGSHL YTYINGRFIK DKVVQHAILQ AYRNFLERGR YPVVAVFIDI APGEVDVNVH
     PTKHEVRFRE QGRVHDAIQK AVESVLKETP WLKRSAVAAA SRPAEKGGGA LRPFSSMEAS
     QAALPVTPQP RPALTPGHPD PPPQAQLQQP LVSESRVAEV RELLVNFQPR PQPPLRPQYR
     GSVAPREGSP YAPIAAAPVP ASEPQSAAQD SDHVAAGYFS SLGVIGQFNA SYILCQRGTD
     LILIDQHAAH ERVAFEKLKG QFAGREVDSQ GLLFPETMEF SFRESAVLRE HQAELARLGF
     EFEEFGGNTW LLKGVPQVLS ATRYVDTIRD ILEELGSLSR SRAFSDIQED LLARIACHSV
     VRGKRTLSPV EIAALFKQMD ETDFSSNCPH GRPVMQTLTL AEVEKMFKRI