ID   MUTL_GEOSW              Reviewed;         619 AA.
AC   C5D9H6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GWCH70_1203;
OS   Geobacillus sp. (strain WCH70).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   unclassified Geobacillus.
OX   NCBI_TaxID=471223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCH70;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Brumm P., Mead D.A., Richardson P.;
RT   "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001638; ACS24062.1; -; Genomic_DNA.
DR   RefSeq; WP_015863534.1; NC_012793.1.
DR   AlphaFoldDB; C5D9H6; -.
DR   SMR; C5D9H6; -.
DR   STRING; 471223.GWCH70_1203; -.
DR   EnsemblBacteria; ACS24062; ACS24062; GWCH70_1203.
DR   KEGG; gwc:GWCH70_1203; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..619
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203390"
FT   REGION          368..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  70318 MW;  15E613CAC6E8EB27 CRC64;
     MGKIRKLDDQ LSNKIAAGEV VERPASVVKE LVENAVDANS TIIEIELEEA GLTKIRVIDN
     GDGMEEDDCL VAFERHATSK IKDEHDLFRI RTLGFRGEAL PSIASVSEVE MKTSTGDGPG
     TKVVLKGGKL VVHERTTSRK GTDITVSNLF FNTPARLKYM KTIHTELGHV TDVVNRLAMA
     HPDISFRLRH HGKQLLYTSG NGDVRHVLAA IYGMDVAKKM IPIQAESLDF TVQGYISLPE
     VTRASRNYIS TIVNGRYVRN IPLAKAIEAG YHTLLPIGRY PIVFLSIAMD PILVDVNVHP
     AKLEVRFSKE AELNELVTQA IRQALQARTL IPEMMIKQKE TPKPKAEQTA WTFEHVVKEP
     FVSPLVHVDE PKQVDEPKQS SPVQEPKEEI PSFLPTVESK QNDVDDELVE MDEQTESSDE
     QEHVNDRLPP LYPIGQMHGT YILAQNERGL YIIDQHAAQE RIKYEYFREK VGEVINEVQE
     LLVPLTFHYP TDEYVLIDAH REELAKCGVF LEPFGHNTFI VRSHPSWFPK GEEAEIIEEM
     IQQVIDMKKV DMKQLREKAA ILMSCKRSIK ANEYLRDDEI FALLESLRKT TDPFTCPHGR
     PIIIHFSTYE LEKMFKRVM