ID   MUTL_GEOTN              Reviewed;         645 AA.
AC   A4IMI1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GTNG_1161;
OS   Geobacillus thermodenitrificans (strain NG80-2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=420246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NG80-2;
RX   PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA   Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA   Han W., Peng X., Liu R., Wang L.;
RT   "Genome and proteome of long-chain alkane degrading Geobacillus
RT   thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000557; ABO66535.1; -; Genomic_DNA.
DR   RefSeq; WP_011887175.1; NC_009328.1.
DR   AlphaFoldDB; A4IMI1; -.
DR   SMR; A4IMI1; -.
DR   STRING; 420246.GTNG_1161; -.
DR   EnsemblBacteria; ABO66535; ABO66535; GTNG_1161.
DR   KEGG; gtn:GTNG_1161; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001578; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..645
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010019"
SQ   SEQUENCE   645 AA;  71546 MW;  F3FBC286F9495F9D CRC64;
     MGRIHKLDDQ LANKIAAGEV VERPASVVKE LVENAIDAHS TAVEIELEEA GMTKIRVIDN
     GDGMEEEDCL LAFERHATSK IQDEHDLFRI RTLGFRGEAL PSIASVSEVE LVTSTGSGPG
     TKLVLKGGAL VARERAAGRK GTDITVSNLF FNTPARLKYM KTIHTELGHA ADVVNRLALA
     HPDVSFRLRH HGKTLLATNG SGDVRHVLAA IYGMETAKQM IPIEAESLDF TVRGYISLPE
     VTRASRNYMS LIVNGRYVRN IPLMKAIEAG YHTLLPIGRY PIVFLAIEMD PVLVDVNVHP
     AKLEVRFSKE AELNELITAT IRQAFRQRTL IPSVSADSKT VKAKAEQASW TFAHRVHEPP
     AQPDGKAEGT SDVTAAASLA SEGSLSPLPA AAQADAPAVS EEAEASVFSE RRTGVVNDLP
     AAELKRDAEV EEEPTEACLP ADEQAEEKRA VDRLPPLYPI GQLHGTYILA ENEHGLYMID
     QHAAQERINY EYFREKLGEV TNEVQELLVP LTFEYPADEY ERIAACRDEL ARCGVFLEPF
     GPRAFLVRSH PVWFPKGKEK EIIEEMIEHV LTAKTVDIKQ LREQAAIVMS CKRAIKANQH
     LRTDEIFALL ETLRQTTDPF TCPHGRPIIV HFSTYEIEKL FKRVM