MUTL_GEOUR
ID MUTL_GEOUR Reviewed; 602 AA.
AC A5GEV5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Gura_1770;
OS Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Geobacteraceae; Geotalea.
OX NCBI_TaxID=351605;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1134 / JCM 13001 / Rf4;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M.,
RA Lovley D., Richardson P.;
RT "Complete sequence of Geobacter uraniireducens Rf4.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000698; ABQ25960.1; -; Genomic_DNA.
DR RefSeq; WP_011938666.1; NC_009483.1.
DR AlphaFoldDB; A5GEV5; -.
DR SMR; A5GEV5; -.
DR STRING; 351605.Gura_1770; -.
DR EnsemblBacteria; ABQ25960; ABQ25960; Gura_1770.
DR KEGG; gur:Gura_1770; -.
DR HOGENOM; CLU_004131_4_2_7; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000006695; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..602
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000076698"
SQ SEQUENCE 602 AA; 66161 MW; B6E0B66EC03A67F3 CRC64;
MATRIKILPE NLTNKIAAGE VVERPASVVK ELVENALDAG CSEVVVEIEA GGRRLIKVTD
SGCGMTREDA LLALERHATS KIASDSDLFG LATLGFRGEA LPSIASVSRF ALATREKGAI
EGTEIYAEGG RVKEVKVCGM AEGTVISVRN LFFNTPARLK FMKSSDTEAG HVGDLLTKLA
ISRPDVRFIY NNDGRTIFRA LDADLRERVA TLLGRALSAD LYPLDFHDGP LGVTGLIAKP
ECSRSAASHL YTYINGRFIK DKVVQHAVLQ AYRNFMERGR YPVVVLFITV PADEVDVNVH
PTKHEVRFRE QGRVHDAIQA ALESVLRATP WVRKQAAPQP FASPPPASEA SATRVAEVRE
TLARYSPEKH LQQSFTVPPA ATFQRQQGAV SLPVAAREDD TASDKTESKG YYCSLSVIGQ
FNAAYILCQD GTDLVIIDQH AAHERVAFEK LKAQFAAAQV ESQRLLFPET IELSFKEGAT
LREHLAELGR LGFSLEEFGG ATWLLNAVPR LLSGTDYLRT LRDILEELQT LGRSRTFADA
LEEILSRIAC HSVVRGIHPL NGQEISALFA QMDATEFSSN CPHGRPVLRS LTLPEIERMF
KR