ID   MUTL_GRAFK              Reviewed;         617 AA.
AC   A0LZH8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GFO_0797;
OS   Gramella forsetii (strain KT0803).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Gramella.
OX   NCBI_TaxID=411154;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT0803;
RX   PubMed=17107561; DOI=10.1111/j.1462-2920.2006.01152.x;
RA   Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E.,
RA   Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K.,
RA   Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I.,
RA   Gloeckner F.O.;
RT   "Whole genome analysis of the marine Bacteroidetes'Gramella forsetii'
RT   reveals adaptations to degradation of polymeric organic matter.";
RL   Environ. Microbiol. 8:2201-2213(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU207366; CAL65773.1; -; Genomic_DNA.
DR   RefSeq; WP_011708710.1; NC_008571.1.
DR   AlphaFoldDB; A0LZH8; -.
DR   SMR; A0LZH8; -.
DR   STRING; 411154.GFO_0797; -.
DR   EnsemblBacteria; CAL65773; CAL65773; GFO_0797.
DR   KEGG; gfo:GFO_0797; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000755; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..617
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000058144"
SQ   SEQUENCE   617 AA;  69267 MW;  652056BADA820363 CRC64;
     MSDIIQLLPD HVANQIAAGE VVQRPASVIK ELLENSIDAK ASRIQVVIKD AGKTLIQIVD
     DGIGMSLTDA RMSFERHATS KIKLADDLFS LKTKGFRGEA LASIAAIAHV ELRTKTENDE
     VGTCLKVEGS EVVSQDAFVT PKGTSISVKN LFYNIPARRN FLKSDNVETR HIIDEFQRVA
     LAHPNISFSL LHNGNELFQL PITNFRQRIT NILGGKTNEK LVPVEEDTEI AKISGFVGKP
     EFAKKSRGEQ FFFVNDRFIK SPYLNHAVTA SFEGLLKDKS YPSYFLYLEV DPKSIDINIH
     PTKTEIKFDD EHALYAILKS SIKHSLGQFN VAPILDFERD SELDTPYDYK NKEADAPQVE
     VDRNFNPFQN EGSSKTQFSG GTNFRKDKPA EWESIYSGMQ SETDTDIDIR HIEFESEEVT
     GNLFGAREEQ TEKSTFQVQK KYIVSTLKSG ILVIDQHRAH TRVLYEELLK NITVSSAVSQ
     QLLFPLLLQF NSHEVEMLKE IKDSLEQTGF VFSSIKKEEV EISGIPTLIS ESEVEILLEQ
     LIADFEKDVP DNGFSQTDLL AKSLANSMAV RSGTLLNSAE QQHIVNRLFA CKEPALSPFN
     KTVFTTLSVD ELDKKFA