ID   MUTL_HAEDU              Reviewed;         598 AA.
AC   Q7VN43;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=HD_0743;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE017143; AAP95653.1; -; Genomic_DNA.
DR   RefSeq; WP_010944705.1; NC_002940.2.
DR   AlphaFoldDB; Q7VN43; -.
DR   SMR; Q7VN43; -.
DR   STRING; 233412.HD_0743; -.
DR   EnsemblBacteria; AAP95653; AAP95653; HD_0743.
DR   KEGG; hdu:HD_0743; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; WKHDDLH; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..598
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177946"
SQ   SEQUENCE   598 AA;  66728 MW;  56BC023B2931A70A CRC64;
     MTQHLIHILP PQLANQIAAG EVVERPASVV KELVENSLDA GANHIQIDIE KGGAQLIRLR
     DNGCGIAKQD LTLALTRHAT SKIATLADLE MILSLGFRGE ALASISSVSR LTLTSRTANQ
     TEAWQAYTQG REMNVEIQPA SHPVGTTIEV ANLFFNTPAR RKFLRTDKTE FNHIDEVVRR
     IALAKPTISF TLTHNGKIIR QYRKVADQSV AQQQKRVAAI CGNHFLQQAT HIEWQHGDLH
     LYGWVSSPQL ARPQNDLSYS YVNGRVMRDK IINHAVRQAY AELIPTGDQP AFILFLDLNP
     TELDVNVHPA KHEVRFHQAR LIHGFILQGV QNALQAQLAL TPTDNQTDSV AETKACYTAD
     NNRAAAGSNI FSSTPYPRYS GATNRPTKTA QQCYAELINT DKNDNANVAP IIYAEPLTTQ
     ATPAITETAD PYPHHSQVLA LVENKALLLK EQEHFYVVPL KKLAQLQLTL SLAEKKSQPL
     LIPLSLSLDQ AQAERWQQYQ AQLLDSGFEI KQKHWQGQTR LSIIAVPQCL RQQNLQQLLL
     QLFNQHTDDL ADFFAKNSEL MTTYSLPEGT RLIANIEQQA KTQLADLKLA VDFSAYLT