MUTL_HALOH
ID MUTL_HALOH Reviewed; 644 AA.
AC B8CX97;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Hore_11660;
OS Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562).
OC Bacteria; Firmicutes; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halothermothrix.
OX NCBI_TaxID=373903;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H 168 / OCM 544 / DSM 9562;
RX PubMed=19145256; DOI=10.1371/journal.pone.0004192;
RA Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H.,
RA Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.;
RT "Genome analysis of the anaerobic thermohalophilic bacterium
RT Halothermothrix orenii.";
RL PLoS ONE 4:E4192-E4192(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001098; ACL69916.1; -; Genomic_DNA.
DR RefSeq; WP_012636101.1; NC_011899.1.
DR AlphaFoldDB; B8CX97; -.
DR SMR; B8CX97; -.
DR STRING; 373903.Hore_11660; -.
DR EnsemblBacteria; ACL69916; ACL69916; Hore_11660.
DR KEGG; hor:Hore_11660; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_9; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000000719; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..644
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000123209"
FT REGION 336..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 73221 MW; 1A9707B6E71C2407 CRC64;
MPEIKRLPES VANQISAGEV VERPASVVKE LVENSLDAGS NKILIEIENG GKDLIRVKDN
GHGIPSDEIE IAFDRYATSK ITDINDLYSL KSLGFRGEAL ASIASVSILD IISRTKSQTK
AIKMRLKGGK VISKEPCGAS VGTDIIVKDL FFNTPARYKY LKTTRNEFKH ISNIITREAL
AYPGVNFTLI HNGRIVLKTP GTGKTLDCIY AIYGKEMAQS LVKIDYEDRY IKVSGYISRP
DYYRYNRSYE IFFVNKRAVH NSILNRGVEE AYQGLLPPGA YPVVFLNLKL NPILVDVNVH
PTKKEVKFSR DKVIKEVIQN GINIELSKLD KSPRLKRNIN PLNRDDKTKD KSEYQKIKLP
EDKEQITNKS SDAGILKNQN PLDSQDSILL PSKKNGFYSK KNSQVSQNKF MDINNKLEKT
EINDNYKKDK HYKTDSINIK DNSIKENKNK MDIPIKRVLG QIKNTYIIAE GRDGLYIIDQ
HNAHERILYQ SFIEKYNNSE IVSQPLVVPV NIETTAPEAE VLKSYLPQLE KMGFKLEVFG
INSFIVREVP SLIKKRSNKR VVREVIDKLL EHDKAMKPSE LINEIISYMS CRGAIKAGEY
LDKKEAEQII EGLFKTDNPY RCPHGRPIII HITEDDINKG MGRK