ID   MUTL_HALSA              Reviewed;         659 AA.
AC   Q9HSM6;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=VNG_0159G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE004437; AAG18777.1; -; Genomic_DNA.
DR   PIR; E84176; E84176.
DR   RefSeq; WP_010902072.1; NC_002607.1.
DR   AlphaFoldDB; Q9HSM6; -.
DR   SMR; Q9HSM6; -.
DR   STRING; 64091.VNG_0159G; -.
DR   PaxDb; Q9HSM6; -.
DR   EnsemblBacteria; AAG18777; AAG18777; VNG_0159G.
DR   GeneID; 5953927; -.
DR   KEGG; hal:VNG_0159G; -.
DR   PATRIC; fig|64091.14.peg.113; -.
DR   HOGENOM; CLU_004131_4_1_2; -.
DR   InParanoid; Q9HSM6; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 35865at2157; -.
DR   PhylomeDB; Q9HSM6; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..659
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177999"
FT   REGION          338..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   659 AA;  67918 MW;  1622B48A4AB5B9B8 CRC64;
     MTDRIRALDD ATVARIAAGE VVERPASVVK ELVENSLDAG AASVDVSVDA GGTDRIVVAD
     DGRGMTGDDL RMAVRQHTTS KLDDASGLDG VGTLGFRGEA LYTIGSVAEL TVTTRPRNAG
     DTGARITVDH GDAGSVAPAG HPAGTTVEVT DLFGETPARR KYLKRAATEF GHVNRAVTRY
     ALANPDVAVS LTHDGREVFA TTGTGDVQDA ALAVYGREVA QSLRTVDADP AADSVERVHG
     YVSDPEVTRS TREYLATFVN GRAVTDAVLR EAVLDGYGDQ LAPDRYPFAV LFVDCEGVDA
     NVHPRKLEVR FEDEAGVKAA VEAGVRDALL DAGLVRAGAP RGASKPGDAE ISPEHSPTDR
     DAGAAGGGDA AGQSDGNGQR TAASGATSES PASAFETGGG DEAADSAAST DGTRERPGSG
     TESRTGRFDA PAENARLPTG AGGPEADDQD TTSERDSLPD LRVLGQLHDT YVVAEAGDGL
     VLVDQHAADE RVHYERLQAR VDGASQALVA PAELELTAGE AAVFEAALGG LRELGFDAEL
     AGRTARVTAV PAVLADALDA ELARDVLSSF LADADGTPVA DAADAVLADL ACSPAIKGNT
     SLAEGSVVAL LDALDACENP YACPHGRPTI VEVDGDELAA RFERDYPGHA GRRREDAGN