ID   MUTL_HERAR              Reviewed;         612 AA.
AC   A4G289;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=HEAR0406;
OS   Herminiimonas arsenicoxydans.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Herminiimonas.
OX   NCBI_TaxID=204773;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ULPAs1;
RX   PubMed=17432936; DOI=10.1371/journal.pgen.0030053;
RA   Muller D., Medigue C., Koechler S., Barbe V., Barakat M., Talla E.,
RA   Bonnefoy V., Krin E., Arsene-Ploetze F., Carapito C., Chandler M.,
RA   Cournoyer B., Cruveiller S., Dossat C., Duval S., Heymann M., Leize E.,
RA   Lieutaud A., Lievremont D., Makita Y., Mangenot S., Nitschke W., Ortet P.,
RA   Perdrial N., Schoepp B., Siguier P., Simeonova D.D., Rouy Z., Segurens B.,
RA   Turlin E., Vallenet D., van Dorsselaer A., Weiss S., Weissenbach J.,
RA   Lett M.-C., Danchin A., Bertin P.N.;
RT   "A tale of two oxidation states: bacterial colonization of arsenic-rich
RT   environments.";
RL   PLoS Genet. 3:518-530(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CU207211; CAL60626.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4G289; -.
DR   SMR; A4G289; -.
DR   STRING; 204773.HEAR0406; -.
DR   EnsemblBacteria; CAL60626; CAL60626; HEAR0406.
DR   KEGG; har:HEAR0406; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_4; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000006697; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..612
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010024"
SQ   SEQUENCE   612 AA;  66235 MW;  B3945A1079DA0296 CRC64;
     MHASSPSVRP IQALSDQLIS QIAAGEVVER PSAVVKELLE NALDAGATHI SVRLEQGGVK
     RIAITDNGRG IAPEQLPLAL ARHATSKINS LTELENVATL GFRGEALASI ASVSQLTLTS
     RTADAAHAWE ISGVQSIDQK STVAPSSGTA GTTVDVLDLY FNTPARRKFL KTEQTEFGHC
     AEVVRRIALS RPDVAFSLTH NGKTIDHWAV NDIARRSAHI LGNEFSAARL PLKETAGPLR
     LHGFIGLPTA SKARGDAQYF YVNGRFVRDK LLMHAVRSAY QDVLHGDRYP SYVISLELDP
     ALVDVNVHPS KIEVRFRDSR AVHQFVFHAV TRALAQTSAT AFGAAPSPTP APSSALPWLR
     EQQQSTFAPQ FNSPYGVAQS AANYGALFAN GPASNDSNSA APSLHTAGSH GATTLPDDEF
     PLGFALAQLH GIFILAQNTK GLVLVDMHAA HERILYEQLK HALDDNELQV QPLLIPITFY
     ADGMEVGTTE DNQDILHALG FDIAALSPTT LAVRAVPALL KNADAQTLAR DVLRDVREFG
     GSRVLLERRN ELLGTLACHT AVRANRTLTV PEMNALLRQM EATERADQCN HGRPTWVQLG
     LSDLDKLFER GR