ID   A13CA_XENLA             Reviewed;         510 AA.
AC   Q6NRD0;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Ankyrin repeat domain-containing protein 13C-A;
GN   Name=ankrd13c-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a molecular chaperone for G protein-coupled
CC       receptors, regulating their biogenesis and exit from the ER.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}.
CC       Note=Associated with the cytosolic side. {ECO:0000250}.
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DR   EMBL; BC070826; AAH70826.1; -; mRNA.
DR   RefSeq; NP_001084851.1; NM_001091382.1.
DR   AlphaFoldDB; Q6NRD0; -.
DR   SMR; Q6NRD0; -.
DR   DNASU; 431897; -.
DR   GeneID; 431897; -.
DR   KEGG; xla:431897; -.
DR   CTD; 431897; -.
DR   Xenbase; XB-GENE-5828147; ankrd13c.L.
DR   OMA; TGNHFRS; -.
DR   OrthoDB; 425969at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 431897; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR021832; ANKRD13.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR12447; PTHR12447; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF11904; GPCR_chapero_1; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Chaperone; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Repeat.
FT   CHAIN           1..510
FT                   /note="Ankyrin repeat domain-containing protein 13C-A"
FT                   /id="PRO_0000240648"
FT   REPEAT          80..111
FT                   /note="ANK 1"
FT   REPEAT          112..141
FT                   /note="ANK 2"
FT   REPEAT          145..174
FT                   /note="ANK 3"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   510 AA;  58219 MW;  06E820DD5CABD9A9 CRC64;
     MTGEKIRSLH KDQKPSKDED LLEPDEEATA GGTFTRTGKL KSSKMFSNHK VIRSPSNPAL
     LQNHHHQQIS PITPGESKSD VYFPVHECVL KGDIRRLSSL IRSHSIGQKD SHGNTPLHLA
     VMLGNKECAH LLLAHNAPVK VKNAQGWSPL AEAISYGDRQ MITALLRKLK QQSRESVEEK
     RPRLLKALKE LGDFYLELHW DFQSWVPLLS RILPSDACKI YKQGINIRLD TTLIDFTDMK
     CQRGDLSFIF NGDAAPSESF VVLDNEQKVY QRIHHEESEM ETEEEVDILM SSDIYSATLS
     TKSITFTRAQ TGWLFREDKT ERVGNFLADF YLVNGLILES RKRREHLTEE DILRNKAIME
     SLSKGGNLME QNFEPVRRQS LTPPPPNTIT WEEYISAENG KAPHLGRELV CKENKKTFKA
     TIAMSQDFPL GIESLLNVLE VIAPFKHFNK LREFVQMKLP PGFPVKLDIP VFPTITATVT
     FQEFRYGEFE DAIFTIPDDY KEDPSRFPDL