ID   MUTL_HISS2              Reviewed;         615 AA.
AC   B0UUU5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=HSM_1568;
OS   Histophilus somni (strain 2336) (Haemophilus somnus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=228400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2336;
RG   US DOE Joint Genome Institute;
RA   Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F.,
RA   Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M.,
RA   Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S.,
RA   Dyer D.W., Inzana T.J.;
RT   "Complete sequence of Haemophilus somnus 2336.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000947; ACA31327.1; -; Genomic_DNA.
DR   RefSeq; WP_012340708.1; NC_010519.1.
DR   AlphaFoldDB; B0UUU5; -.
DR   SMR; B0UUU5; -.
DR   STRING; 228400.HSM_1568; -.
DR   EnsemblBacteria; ACA31327; ACA31327; HSM_1568.
DR   KEGG; hsm:HSM_1568; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; WKHDDLH; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..615
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076699"
SQ   SEQUENCE   615 AA;  70177 MW;  199A6082BC5E95B3 CRC64;
     MTIKILPPQL ANQIAAGEVV ERPASVVKEL IENSLDAGAT HIQIEIENGG ANLIRIRDNG
     IGIAKDELHL ALARHATSKI ASLDDLEMIL SLGFRGEALA SISSVSRLTL TSRTAQQNEA
     WQVYAQGRDM ETSITPASHP IGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL
     AKPQVAFTLT HNNKLIHRYK SAVTNEQKIK RIATICGNDF MQNALHIDWK HNDLHLSGWV
     IQPQFARHQN DLNYCYINGR MVKDKVITHA IRQAYSEYLS NEKYPAFVLF IDLNPNEVDV
     NVHPTKHEVR FHQARLIHDF IYQGMTNALT SEQTNIPIQS EQSNPTKVAE PQGIWNLTTH
     NKGNRATAGK NIFAQQPKDY DKKSSQFKPH FAANYSEVTP KKAVQKAYAE LLATHEEKTI
     ASSTLPHQFT HNATHISEQK NVLHALALIE NKALLLQQNQ QYFLLSIQAL QHFNIRLQLQ
     QSNIAQQTLL IPILLRLNKQ QYQSWQQQAL FFQQSGFDFT DNSAQRRITL NRLPICLRTQ
     NIQKIILQLL DQPHEKYTIF LTALCSHLEF PSLSTFSEAV NLLTKTEQQF STQHQLEFQS
     LLVKIEWDHY LDKLQ