ID   MUTL_JANMA              Reviewed;         613 AA.
AC   A6SV55;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=mma_0462;
OS   Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Janthinobacterium.
OX   NCBI_TaxID=375286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Marseille;
RX   PubMed=17722982; DOI=10.1371/journal.pgen.0030138;
RA   Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D.,
RA   Drancourt M.;
RT   "Genome analysis of Minibacterium massiliensis highlights the convergent
RT   evolution of water-living bacteria.";
RL   PLoS Genet. 3:1454-1463(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000269; ABR88766.1; -; Genomic_DNA.
DR   RefSeq; WP_012078327.1; NC_009659.1.
DR   AlphaFoldDB; A6SV55; -.
DR   SMR; A6SV55; -.
DR   STRING; 375286.mma_0462; -.
DR   EnsemblBacteria; ABR88766; ABR88766; mma_0462.
DR   KEGG; mms:mma_0462; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_4; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; JSP375286:MMA_RS02395-MON; -.
DR   Proteomes; UP000006388; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..613
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010025"
SQ   SEQUENCE   613 AA;  66620 MW;  A542E163E9E29B20 CRC64;
     MHATTQPFRP IQPLSDQLIS QIAAGEVVER PSAVVKELLE NALDAGATAI TVRLEQGGVK
     RIAITDNGRG ITPEQLPLAL ARHATSKINS LNELENVGTL GFRGEALASI ASVAQLTLTS
     RTADAQHAWE ISGVQGSDQK NTVAPSSGAP GTTVDVQDLY FNTPARRKFL KTEQTEFGHC
     AEVVRRIALS RPDVAFSLSH NGKTVDHWAV NDIAKRSAHI LGSEFSGARL PLEETAGPLH
     LHGFIGLPTA SKARGDAQYF YVNGRFVRDK LLMHAVRSAY QDVLHGDRYP SYVISLDLDP
     ALVDVNVHPS KIEVRFRDSR SVHQFVFHAV SRALAQTSAT AFGAVPSPTP APSGALPWLR
     EQQQTTFAPQ FQQQYGVAQT TANYGALFNT DGAVTPLGTE PAPAFAAFTN SPAQTMSDDE
     FPLGFALAQL HGIFILAQNT KGLVLVDMHA AHERILYEQL KNALDDNAMQ VQPLLIPITF
     YADDVEVGTA EDSKETLLSL GFDIAVMSPT TLAIRAVPTL LKNADAQSLA RDVLRDVREY
     GGSRVLVERR NELLGTLACH TAVRANRMLT GPEMNALLRQ MEATERADQC NHGRPTWVQL
     GLSDLDKLFE RGR