ID   MUTL_KORVE              Reviewed;         647 AA.
AC   Q1ILN0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Acid345_3219;
OS   Koribacter versatilis (strain Ellin345).
OC   Bacteria; Acidobacteria; Acidobacteriales; Acidobacteriaceae;
OC   Candidatus Koribacter.
OX   NCBI_TaxID=204669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ellin345;
RX   PubMed=19201974; DOI=10.1128/aem.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000360; ABF42220.1; -; Genomic_DNA.
DR   RefSeq; WP_011524019.1; NC_008009.1.
DR   AlphaFoldDB; Q1ILN0; -.
DR   SMR; Q1ILN0; -.
DR   STRING; 204669.Acid345_3219; -.
DR   PRIDE; Q1ILN0; -.
DR   EnsemblBacteria; ABF42220; ABF42220; Acid345_3219.
DR   KEGG; aba:Acid345_3219; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002432; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..647
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076685"
SQ   SEQUENCE   647 AA;  71547 MW;  05F77441F16CD275 CRC64;
     MGRIHVLSEH VANKIAAGEV VERPASVVKE LIENSLDAGA KRIRVHVEAG GKKLIHIVDD
     GIGMFRDDAM LAFERHATSK LKNPEDLLSI STLGFRGEAL PSIASVARVR LETRANEEPS
     GTVLEIAGGK ILKIEEAGLP LGTSIAIKDL FFNTPARKKF LKSESTELSH IASLVTHYAL
     AHPEMHWELH SATNALLIAP PVATQSERIY QVFGNETLDQ LIPLAAQIKL ERIGLPKPPP
     WLRKNEDDEE EQTVEPGEVR LHGFISKPEI QKLNRNSIFV FVNGRLIRDR LVQHALTEAY
     RNILPPTLFP VVLLFLEMPY TEVDVNVHPS KTEVRFRQQS LVHDFVRDSV RAALSKARPI
     PQFISEIHAQ PKASPSLTPG AQTAPAFALE AQEEPVLPER LQFGGDAISV EANAAVPVAR
     FGAQTFGSHV AQQQTVPETS GCDYELPDLP AADAPLASLR PLGQIRESFI LATSNEGLWI
     IDQHVAHERV LFEKVLKQRA AASVETQQLL MPLIVELTPG QQAVFTEIAE ELHQNGFEVE
     PFGSRTFAVK AAPAGIRAED IEKTLSEVLD SFEREQQAFN LEHAQSRIAA TIACHAAIKV
     NMPLTQDKME WLLAELAKTE HPMTCPHGRP IVLRYSVKDI QKAFKRI