ID   MUTL_LACAC              Reviewed;         631 AA.
AC   Q5FLX4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LBA0409;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000033; AAV42300.1; -; Genomic_DNA.
DR   RefSeq; WP_003549162.1; NC_006814.3.
DR   RefSeq; YP_193331.1; NC_006814.3.
DR   AlphaFoldDB; Q5FLX4; -.
DR   SMR; Q5FLX4; -.
DR   STRING; 272621.LBA0409; -.
DR   PRIDE; Q5FLX4; -.
DR   EnsemblBacteria; AAV42300; AAV42300; LBA0409.
DR   GeneID; 56942014; -.
DR   KEGG; lac:LBA0409; -.
DR   PATRIC; fig|272621.13.peg.394; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   BioCyc; LACI272621:G1G49-403-MON; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..631
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010027"
SQ   SEQUENCE   631 AA;  71159 MW;  FE0C367A9DA3FFAE CRC64;
     MPKIHELSET LTNQIAAGEV IERPASVVKE LVENSLDAGA TRIRVDFVDA GLKQIVVQDN
     GTGIARDQVD LAFTRHATSK ISNEHDLFKV ATLGFRGEAL ASISAVSHVE ILTATKGAIG
     VKATFSGGNK KGQEDAAARE GTQITVRDLF FNTPARLKYL RSPRTEIMKI VDIINRLALG
     YPSVSFTLSN TGKVLLRTPG NGNLKQTVAN VYGRHIAEKM EEFEAKDNDF KISGLMSKPE
     LTRSTRNFVS ILLNGRYIRN FQLNTAIMDG YGAKLAARHY PIIVLAIQVD PLLVDVNVHP
     TKQEVRLSKE KELSRLITST ISNVFIKKTE QTSAFANLEN KRETLVDQLQ FNLNQNVVNT
     ARKKTPEIHE NNEKPEFLAK PKKPEEEKTD YVDLNIPRED DKYIITKTWD KNVLLQQDLR
     PFSNTLCDSE VISSGDETLA NNLPQLSYIG QIDTYIIAEN NSDLFLIDQV AARRRLQFEK
     IYEMLLSKKI VQQGLLTPIV LEFGNLDFIQ IKDKIDQIKQ IGIYLEDFGQ NSFIVRSYPT
     WIHNDVEETI RQILDGYLNL DKGKSENLFK RVAAMQAKRD ISGKINLAAA EASQILIDLR
     KTEDPYHDAD GRLVLVRMSE NELKKMFKRD K