ID   MUTL_LACCB              Reviewed;         651 AA.
AC   B3W9W3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LCABL_24160;
OS   Lacticaseibacillus casei (strain BL23) (Lactobacillus casei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=543734;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL23;
RA   Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A.,
RA   Deutscher J.;
RT   "Lactobacillus casei BL23 complete genome sequence.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; FM177140; CAQ67482.1; -; Genomic_DNA.
DR   RefSeq; WP_003606620.1; NC_010999.1.
DR   AlphaFoldDB; B3W9W3; -.
DR   SMR; B3W9W3; -.
DR   KEGG; lcb:LCABL_24160; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..651
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096659"
FT   REGION          383..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  72173 MW;  C0B6FCC5323E5F81 CRC64;
     MPKIHQLSAT LSNQIAAGEV IERPASVVKE LVENSIDAQA TQIDVLISAA GLQEIRVSDN
     GIGIAPDDVA TAFLRHATSK ILTTRDLFNV HSLGFRGEAL ASIAAVADVK LTTAMDSGIG
     TQIHVKGGEV EAQSTAAHRR GTDVEVNDLF FNTPARLKYM KSQQTELGKI VDIVSRLAMA
     NPDIAFTVSH DGNMVVRTAG QGDLRQTLAG IYGLSVARSM VDFKAQDLDF RVSGLTSLPE
     TTRASRNYLS LVVNGRYIKN FQLTKAVIAG YGSKLMVGRY PMGVINIEMD AALVDVNVHP
     TKAEVRLSKE DQLSHLLSEA IRTRLAKENL IPDALDNLPK RERYDLDQLE LTLNKISPKT
     MPSVQPQQGQ QLRENTTTNL ADTAAEEPTP APTSPDLEIG DLDDQPIFNE PQRLAAWDQR
     YQRLASNVVP TLMADEPEPD ISHVESAERF PNLTYLAQVH GTYLLAESGD GLYILDQHAA
     QERVNYEYYR QAIGEVSNDQ QHLLVPIVLD YSAADAISIR DHRDVLESVG LYLEDFGQNS
     FVVEHHPTWF KAGQEEDTIK EMVDWVLRDG RMTVAAFREK TAIMMSCKRA IKANHHLDDR
     QARALLQKLP ECENPFNCPH GRPVLVHFSN TDLEKMFKRI QDSHESGEMQ A