ID   MUTL_LACDA              Reviewed;         653 AA.
AC   Q1G939;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Ldb1615;
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081
OS   / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM
OS   00102 / Lb 14).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=390333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB
RC   11778 / NCTC 12712 / WDCM 00102 / Lb 14;
RX   PubMed=16754859; DOI=10.1073/pnas.0603024103;
RA   van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K., Nicolas P.,
RA   Robert C., Oztas S., Mangenot S., Couloux A., Loux V., Dervyn R., Bossy R.,
RA   Bolotin A., Batto J.-M., Walunas T., Gibrat J.-F., Bessieres P.,
RA   Weissenbach J., Ehrlich S.D., Maguin E.;
RT   "The complete genome sequence of Lactobacillus bulgaricus reveals extensive
RT   and ongoing reductive evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CR954253; CAI98404.1; -; Genomic_DNA.
DR   RefSeq; WP_011544116.1; NZ_JQAV01000002.1.
DR   AlphaFoldDB; Q1G939; -.
DR   SMR; Q1G939; -.
DR   STRING; 390333.Ldb1615; -.
DR   PRIDE; Q1G939; -.
DR   EnsemblBacteria; CAI98404; CAI98404; Ldb1615.
DR   KEGG; ldb:Ldb1615; -.
DR   PATRIC; fig|390333.13.peg.1009; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_9; -.
DR   OMA; AHERIMY; -.
DR   BioCyc; LDEL390333:LDB_RS06980-MON; -.
DR   Proteomes; UP000001259; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..653
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010030"
FT   REGION          368..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..413
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   653 AA;  72442 MW;  E06CC9CDFE2AA894 CRC64;
     MAKIHELSEN LTNQIAAGEV IERPASVVKE LVENAIDAQA SRIRVEVQHS GLKQISVQDN
     GSGIAPDQVD LAFMRHATSK IQDEHDLFNI ATLGFRGEAL ASIAAVAHVE ILTSTGGQTA
     TRAAFAGGVK KFQEDAGSAK GTKITVGDIF YNTPARLKYL KSPKTELLKI VDIVNRIALG
     HPEISLTLAS DGKVLLRTPG NGNLKQDVAN IYGRKVAEKM LTVENEDPDF TLYGLVSEAN
     LTRSSRNFIS ILLNGRYIKN YQLSSALLDG YGNKLGGKYP IAVLAIEADP LLVDVNVHPT
     KEEVRLSKEK ELSRLITSAV TEALMDEDEA SPLFQLTPFK DKTQLDQLEF NLKPNVVDTR
     RPDDFQLEVS QVAEPEGKTD ITNKKETETK EKAEKKENKQ EEKEEKTSAP EYVDLNQVRE
     DDQYVLTKSW DQHVKEQTAL PPFAGGEEAA SPVTSKADQL LRQHLPALRL LGQMGGYLLA
     EHEGDLYLID QVAARRRLEY DQILASLEKD ENYQQGLLEP LVFDFSVYDY QKLKDQLPLL
     RQLGLEMEDF GQNTLLMHSY PTWLKGEVTV QVRELLDQLL SSRENDGKSL LKLVAAKAAE
     SNVSRRVNLT GAEAADLLLR LQTASDPYRD ASGQLAVVRL SQNDLSKLFK KGK