ID   MUTL_LACH4              Reviewed;         636 AA.
AC   A8YTI0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=lhv_0428;
OS   Lactobacillus helveticus (strain DPC 4571).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=405566;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DPC 4571;
RX   PubMed=17993529; DOI=10.1128/jb.01295-07;
RA   Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K.,
RA   McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F.,
RA   Beresford T., Ross R.P.;
RT   "Genome sequence of Lactobacillus helveticus: an organism distinguished by
RT   selective gene loss and IS element expansion.";
RL   J. Bacteriol. 190:727-735(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000517; ABX26636.1; -; Genomic_DNA.
DR   RefSeq; WP_012211440.1; NC_010080.1.
DR   AlphaFoldDB; A8YTI0; -.
DR   SMR; A8YTI0; -.
DR   STRING; 405566.lhv_0428; -.
DR   EnsemblBacteria; ABX26636; ABX26636; lhv_0428.
DR   KEGG; lhe:lhv_0428; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000790; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..636
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000071507"
FT   REGION          362..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  71776 MW;  CB7C9C49CEF3B63F CRC64;
     MAKIHELSEN LTNQIAAGEV IERPASVVKE LVENSLDAGA TRIRVDFIDA GLKQIVVQDN
     GTGIARDQVD LAFTRHATSK ISNEHDLFKV STLGFRGEAL ASISAVSHVE IVTATENAIG
     IKADFSGGSK KGQEDAASQK GTKITVRDLF FNTPARLKYL RSPRTEIMKI VDIINRLSLG
     YPHVSFTLSN TGKVLFRTTG NGNLKQTVAN VYGRHIAEKM ESFEAKDSDF KITGLMSKPE
     LTRSTRNFIS ILLNGRYIKN FQLNNAIMDG YGSKLAARHY PIVVITIHVD PMLVDVNVHP
     TKQEVRLSKE KELSRLITDA ISDALLDKTE QSSGFANLEN KRETLVDQLE FNLNQDVVNT
     TRKTPEVHEE AEKPEFLVKQ EAKNSEEPKN ETEHNYVDIN IPREDDQYII TKTWDKNVAL
     QQKLMPFSNK KVDQEVISTG DETLANNLPR LAYVGKIDTY LLAENDGDLY LIDQVAARRR
     LQFEQIYQTI TSKKIVQQGL LTPIVLEFGN LDFLQIKDKI YQIKQLGIYL DEFGQNSFIV
     RSYPTWIHDH VEESIREILD NYLNLDKGKT QNLFKRVAAL EAKRSVKGKI NLSAAEGTQI
     ITDLRKTSDP YHDADGRLIL VRISQNELRK MFKKGE