ID   MUTL_LACJO              Reviewed;         630 AA.
AC   Q74KW0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LJ_0466;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT   johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE017198; AAS08458.1; -; Genomic_DNA.
DR   RefSeq; WP_011161603.1; NC_005362.1.
DR   AlphaFoldDB; Q74KW0; -.
DR   SMR; Q74KW0; -.
DR   STRING; 257314.LJ_0466; -.
DR   EnsemblBacteria; AAS08458; AAS08458; LJ_0466.
DR   KEGG; ljo:LJ_0466; -.
DR   PATRIC; fig|257314.6.peg.493; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000581; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..630
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010033"
SQ   SEQUENCE   630 AA;  71188 MW;  4B456B442FACE2C5 CRC64;
     MSKIHELSPE LTNQIAAGEV IERPASVVKE LCENSLDAGS KRIRIDFIDA GLKQITVQDN
     GSGIAKDQID LAFTRHATSK IATERDLFNI STLGFRGEAL ASIAAVSHVE VTTSNDNLGG
     VRAIFSGSEK KLQEDAASPK GTKITVSDLF FNTPARLKYL RSERTEILKI VDIVNRLALG
     HPDVSFTLTN NGKVLLKTNG RDDLRQDIAN IYGRQLAEKM NILKGKSPDF EISGLISDPN
     TTRSNRNFIS LLLNGRYIKN YRLTQAIMAG YGNKLRPRRY PIAVVKIELD PLLVDVNVHP
     TKQEVRLSKE QELERLLTTS ISEALEQNNQ IDSGLNNLLA PKKSTNIDQL KFNLNKDVVN
     TARPVEFTPQ VEPDQNAEVH ETGANFVSLD QVRNDDKYVI TSTWNDNVNQ QVQLSPFDEE
     KDMQGKDDSI ISSGDEILAN NLPELTYMGQ TKSYLIAHHE EDLYLIDQVN AYRRLAYDQI
     LQDLNSENIS QQGLLSPLIL DFSNVDYLKL KENLENLQEF GLFLEDFGQN SLILRTYPMW
     LQPDAEKNVR MILDLYLNQT EHDISKLKAQ IAGEITMRQS ARRRMLNPVE AQELLKELRN
     SSDPYQDFEG KIIIIQLSEN DLNKMFKKDE