ID   MUTL_LACLA              Reviewed;         656 AA.
AC   Q9CDL1;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; Synonyms=hexB;
GN   OrderedLocusNames=LL2208; ORFNames=L0276;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK06306.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005176; AAK06306.1; ALT_INIT; Genomic_DNA.
DR   PIR; H86900; H86900.
DR   RefSeq; NP_268365.1; NC_002662.1.
DR   RefSeq; WP_031297070.1; NC_002662.1.
DR   AlphaFoldDB; Q9CDL1; -.
DR   SMR; Q9CDL1; -.
DR   STRING; 272623.L0276; -.
DR   PaxDb; Q9CDL1; -.
DR   EnsemblBacteria; AAK06306; AAK06306; L0276.
DR   KEGG; lla:L0276; -.
DR   PATRIC; fig|272623.7.peg.2372; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..656
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177948"
SQ   SEQUENCE   656 AA;  73712 MW;  9C39FB7E3C0F2A20 CRC64;
     MGKIIELNEA LANQIAAGEV VERPASVVKE LVENSIDAGS SKIIINVEEA GLRLIEVIDN
     GLGLEKEDVA LALRRHATSK IKDSADLFRI RTLGFRGEAL PSIASVSQMT IETSTAEEES
     GTKLVAKGGN IETLEPLAKR VGTKISVANL FYNTPARLKY IKSLQAELSH ITDIINRLSL
     AHPEISFTLV NEGKEFLKTA GNGDLRQVIA AIYGIGTAKK MRQIKGSDLD FELTGYVSLP
     ELTRANRNYI TILINGRFIK NFLLNRAILE GYGNRLMVGR FPFAILSIKI DPTLADVNVH
     PTKQEVRLSK ERELMALISK AIDEALSEGV LIPEALENLQ GRAKEKESLS VQTELPLQNN
     PLYYDNVRQD FYVREEATFK INKNQASNDS SEQTFDNFTE NQLNTDAVSE KMTDRTVEST
     TEITDNSLEN TVSNFEIDFD NEAKISQSST FPQLEYLAQL HATYLLCQSK EGLYLVDQHA
     AQERIKYEYW KDKIGEVSME QQILLAPYLF TLAKNDFIVL AEKKDLLHEA GVFLEEYGEN
     QFILREHPIW LKETEIEKSI NEMIDIILSS KEFSLKKYRH DLAAMVACKS SIKANHPLDA
     ESARALLAEL ATCKNPYSCA HGRPTIVHFS GDDIQKMFRR IQETHRSKAA SWKDFE